Glutamine supplementation can reduce some atherosclerosis markers after exhaustive exercise in young healthy males

source extracted confidence: high 2026-04-09
#atherosclerosis #biomarkers #dietary-supplements #exercise #glutamine

Glutamine supplementation can reduce some atherosclerosis markers after exhaustive exercise in young healthy males

Alipanah-Moghadam et al., 2022 | Nutrition | Rct

Citation

Alipanah-Moghadam Reza, Molazadeh Leila, ... Nemati Ali. Glutamine supplementation can reduce some atherosclerosis markers after exhaustive exercise in young healthy males. Nutrition. 2022-Feb;94:111506. doi:10.1016/j.nut.2021.111506

Abstract

OBJECTIVES: Glutamine can be beneficial to athletes for its antiinflammatory and antioxidant effects. The present study was designed to investigate the effect of glutamine supplementation on some atherosclerosis markers after exhaustive exercise in young healthy males. METHODS: In an intervention study, 30 healthy males (case = 15 and control = 15) were randomly assigned into two groups. For 14 d, the intervention group received 0.3 g of glutamine per kilogram of body weight per day, with 25 g of sugar in 250 mL of water, and the control group received 25 g of sugar per 250 mL of water. At the end of the intervention, the participants completed one session of exhaustive exercise, and then fasting blood samples were taken to test serum levels of atherosclerosis markers. RESULTS: In the intervention group, the serum levels of leptin, cholesterol, and oxidized low-density lipoprotein were lower than in the control group after 2 wk of glutamine supplementation (P < 0.05). Interleukin-6 serum levels were lower in the intervention group compared to the control group after supplementation, but not significantly. Serum levels of leptin, interleukin-6, cholesterol, and oxidized low-density lipoprotein, as well as the ratio of oxidized low-density lipoprotein to high-density lipoprotein, were significantly decreased in the intervention group compared to the control group after exhaustive exercise (P < 0.05). CONCLUSIONS: Glutamine supplementation has beneficial effects for athletes, particularly those doing strenuous physical exercise, through reducing atherosclerosis-related biomarkers and elevating serum adiponectin levels, and it can potentially play a role in decreasing the initiation and progression of atherosclerosis.

Key Findings

In the intervention group, the serum levels of leptin, cholesterol, and oxidized low-density lipoprotein were lower than in the control group after 2 wk of glutamine supplementation (P < 0.05). Interleukin-6 serum levels were lower in the intervention group compared to the control group after supplementation, but not significantly. Serum levels of leptin, interleukin-6, cholesterol, and oxidized low-density lipoprotein, as well as the ratio of oxidized low-density lipoprotein to high-density lip

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population young healthy
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Atherosclerosis
  • Biomarkers
  • Dietary Supplements
  • Exercise
  • Glutamine
  • Humans
  • Male

Evidence Classification

  • Level: Rct
  • Publication Types: Journal Article, Randomized Controlled Trial
  • Vertical: glutamine-sports

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09