The effect of chromium intake on oxidative stress parameters: A systematic review and meta-analysis

source extracted confidence: high 2026-04-09
#chromium #dietary-supplements #humans #oxidative-stress #superoxide-dismutase

The effect of chromium intake on oxidative stress parameters: A systematic review and meta-analysis

Morvaridzadeh et al., 2022 | J Trace Elem Med Biol | Meta Analysis

Citation

Morvaridzadeh Mojgan, Estêvão M Dulce, ... Heshmati Javad. The effect of chromium intake on oxidative stress parameters: A systematic review and meta-analysis. J Trace Elem Med Biol. 2022-Jan;69:126879. doi:10.1016/j.jtemb.2021.126879

Abstract

BACKGROUND: Trivalent chromium is a trace element thought to have a beneficial effect on oxidative stress (OS) parameters and inflammation. This review aimed to investigate the dose-response of chromium and summarize the effects of chromium supplementation on OS parameters in the literature. METHODS: MEDLINE, Scopus, Web of Science and Cochrane CENTRAL databases were searched for RCTs published from inception to January 2021 evaluating the effect of chromium supplementation on OS parameters, namely MDA, TBARS, SOD, TAS, CAT, GPx, and GSH. A random-effects model was used to pool data and calculated standard mean difference and 95 % confidence intervals. Quantified heterogeneity among studies was assessed through Cochrane's I2 values. RESULTS: Nine studies enrolling 550 participants met the inclusion criteria. The obtained results indicate that chromium supplementation significantly increases TAC (SMD: 0.46; 95 % CI: 0.08, 0.84; I2 = 00.0 % n = 2) and significantly decreases MDA levels (SMD: -0.46; 95 % CI: -0.86, -0.07; I2 = 52.4 % n = 5). Supplementation did not significantly change CAT, GPx, GSH, SOD, TAS, and TBARS. CONCLUSION: Chromium supplementation may improve OS parameters, however, due to high heterogeneity observed in the included studies, these findings should be interpreted with caution. Large RCTs on various patient groups evaluating the impact of chromium supplementation are needed to allow an adequate generalization of the benefits of chromium on human health.

Key Findings

Nine studies enrolling 550 participants met the inclusion criteria. The obtained results indicate that chromium supplementation significantly increases TAC (SMD: 0.46; 95 % CI: 0.08, 0.84; I2 = 00.0 % n = 2) and significantly decreases MDA levels (SMD: -0.46; 95 % CI: -0.86, -0.07; I2 = 52.4 % n = 5). Supplementation did not significantly change CAT, GPx, GSH, SOD, TAS, and TBARS.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 2
Age Range See abstract
Condition stress

MeSH Terms

  • Chromium
  • Dietary Supplements
  • Humans
  • Oxidative Stress
  • Superoxide Dismutase
  • Thiobarbituric Acid Reactive Substances

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: chromium

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09