Occupational exposure to hexavalent chromium. Part II. Hazard assessment of carcinogenic effects

source extracted confidence: high 2026-04-09
#animals #chromium #databases-factual #humans #neoplasms

Occupational exposure to hexavalent chromium. Part II. Hazard assessment of carcinogenic effects

den et al., 2021 | Regul Toxicol Pharmacol | Systematic Review

Citation

den Braver-Sewradj Shalenie P, van Benthem Jan, ... Hessel Ellen V S. Occupational exposure to hexavalent chromium. Part II. Hazard assessment of carcinogenic effects. Regul Toxicol Pharmacol. 2021-Nov;126:105045. doi:10.1016/j.yrtph.2021.105045

Abstract

Hexavalent chromium (Cr(VI)) compounds have been studied extensively and several agencies have described their toxicological profile. In the past, personnel of the Dutch Ministry of Defence may have been exposed to Cr(VI) during maintenance activities on NATO equipment. To investigate if this exposure may have caused irreversible adverse health effects, the Dutch National Institute for Public Health and the Environment (RIVM) summarized all available knowledge from previous evaluations. This information was complemented with a scoping review to retrieve new scientific literature. All scientific evidence was evaluated in workshops with external experts to come to an overview of irreversible adverse health effects that could be caused by occupational exposure to Cr(VI) compounds. This review provides the hazard assessment for occupational exposure to Cr(VI) and carcinogenic effects by integrating and weighting evidence provided by international agencies complemented with newly published studies. It was concluded that occupational exposure to Cr(VI) can cause lung cancer, nose and nasal sinus cancer in humans. Cr(VI) is suspected to cause stomach cancer and laryngeal cancer in humans. It is currently insufficiently clear if Cr(VI) can cause cancer of the small intestine, oral cavity, pancreas, prostate or bladder in humans.

Key Findings

It is currently insufficiently clear if Cr(VI) can cause cancer of the small intestine, oral cavity, pancreas, prostate or bladder in humans.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Animals
  • Chromium
  • Databases, Factual
  • Humans
  • Neoplasms
  • Netherlands
  • Occupational Exposure
  • Occupational Health
  • Risk Assessment

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: chromium

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09