A systematic review of carbohydrate-based bioactive molecules for Alzheimer's disease

source extracted confidence: high 2026-04-09
#acetylcholinesterase #alzheimer-disease #animals #butyrylcholinesterase #carbohydrates

A systematic review of carbohydrate-based bioactive molecules for Alzheimer's disease

Bajad et al., 2021 | Future Med Chem | Systematic Review

Citation

Bajad Nilesh Gajanan, Swetha Rayala, ... Singh Sushil Kumar. A systematic review of carbohydrate-based bioactive molecules for Alzheimer's disease. Future Med Chem. 2021-Oct;13(19):1695-1711. doi:10.4155/fmc-2021-0109

Abstract

The abundance, low cost, high density of functional groups and ease of purification of carbohydrates are among the most important features that make them a prime candidate for designing therapeutics. Several carbohydrate-based molecules, of both natural and synthetic origin, are known for their wide range of therapeutic activities. The incorporation of a carbohydrate moiety not only retains the pharmacological characteristics of a molecule but also improves its activity. Several sugar conjugates have been designed and reported to inhibit acetylcholinesterase, β-amyloid and tau aggregation. This systematic review provides a brief overview of carbohydrate-based bioactive molecules having anti-Alzheimer's activity along with improved therapeutic potential. Most importantly, several reported carbohydrate-based molecules for Alzheimer's disease act on β-amyloid aggregation, tau protein, cholinesterase and oxidative stress, with enhanced pharmacokinetic and mechanistic properties. The prospect of designing carbohydrate-based molecules for Alzheimer's disease will definitely provide potential opportunities to discover novel carbohydrate-based drugs.

Key Findings

The prospect of designing carbohydrate-based molecules for Alzheimer's disease will definitely provide potential opportunities to discover novel carbohydrate-based drugs.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition stress

MeSH Terms

  • Acetylcholinesterase
  • Alzheimer Disease
  • Animals
  • Butyrylcholinesterase
  • Carbohydrates
  • Cholinesterase Inhibitors
  • Humans
  • Molecular Structure
  • Neuroprotective Agents

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Research Support, Non-U.S. Gov't, Systematic Review
  • Vertical: curcumin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09