A Systematic Review and Meta-Analysis on the Efficacy of Curcumin/Turmeric for the Prevention and Amelioration of Radiotherapy/Radiochemotherapy Induced Oral Mucositis in Head and Neck Cancer Patients

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#anti-inflammatory-agents-non-steroidal #chemoradiotherapy #curcumin #head-and-neck-neoplasms #humans

A Systematic Review and Meta-Analysis on the Efficacy of Curcumin/Turmeric for the Prevention and Amelioration of Radiotherapy/Radiochemotherapy Induced Oral Mucositis in Head and Neck Cancer Patients

Dharman et al., 2021 | Asian Pac J Cancer Prev | Meta Analysis

Citation

Dharman Sreedevi, G Maragathavalli, ... Sampath Rajesh Kumar. A Systematic Review and Meta-Analysis on the Efficacy of Curcumin/Turmeric for the Prevention and Amelioration of Radiotherapy/Radiochemotherapy Induced Oral Mucositis in Head and Neck Cancer Patients. Asian Pac J Cancer Prev. 2021-Jun-01;22(6):1671-1684. doi:10.31557/APJCP.2021.22.6.1671

Abstract

BACKGROUND: Oral Mucositis(OM) is an acute debilitating dose limiting toxicity of Radiotherapy/Radiochemotherapy(RT/RCT) in management of Head and Neck Cancer (HNC). Curcumin/Turmeric may reduce OM in patients. AIM: Efficacy of Curcumin/Turmeric for preventing and ameliorating the onset and severity of RT/RCT induced OM was analysed in this review. METHODS: A systematic literature search with meta-analysis were performed using Mesh terms in PubMed, Google scholar, Science Direct, Cochrane library and manual searching, articles published from 2010 to April 2021 were included. Clinical trials that studied the efficacy/effects of turmeric / curcumin in management of RT/RCT induced OM in HNC patients were included. Statistical Analysis were done to calculate the pooled Risk ratio at 95%confidence interval with significance at p.

Key Findings

Statistical Analysis were done to calculate the pooled Risk ratio at 95%confidence interval with significance at p.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Anti-Inflammatory Agents, Non-Steroidal
  • Chemoradiotherapy
  • Curcumin
  • Head and Neck Neoplasms
  • Humans
  • Stomatitis

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: curcumin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09