Supplementation of Omega 3 during Pregnancy and the Risk of Preterm Birth: A Systematic Review and Meta-Analysis

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#adult #dietary-supplements #fatty-acids-omega-3 #female #humans

Supplementation of Omega 3 during Pregnancy and the Risk of Preterm Birth: A Systematic Review and Meta-Analysis

Serra et al., 2021 | Nutrients | Meta Analysis

Citation

Serra Ramón, Peñailillo Reyna, ... Illanes Sebastián E. Supplementation of Omega 3 during Pregnancy and the Risk of Preterm Birth: A Systematic Review and Meta-Analysis. Nutrients. 2021-May-18;13(5). doi:10.3390/nu13051704

Abstract

Preterm birth (PTB) is a major cause of neonatal death and long-term consequences for the newborn. This review aims to update the evidence about the potential benefit of pharmacological supplementation with omega 3 fatty acids during pregnancy on the incidence of PTB. The Medline, Embase, Cochrane Library and Central databases were searched until 28 June 2020 for RCTs in which omega 3 supplementation was used versus placebo to reduce PTB risk. Data from 37 trials were analyzed. We found an 11% reduction in PTB risk (RR(risk ratios), 0.89; 95% CI (confidence intervals), 0.82 to 0.97) in trials using omega 3 supplements versus placebo. Regarding early PTB (ePTB), there was a 27% reduction in the risk of ePTB (RR, 0.73; 95% CI, 0.58 to 0.92). However, after sensitivity analyses, there were no significant differences in PTB and ePTB risk (PTB RR, 0.92; 95% CI, 0.83 to 1.01, ePTB RR, 0.82; 95% CI, 0.61 to 1.09). We conclude that omega 3 supplementation during pregnancy does not reduce the risk of PTB and ePTB. More studies are required to determine the effect of omega 3 supplementations during pregnancy and the risk of detrimental fetal outcomes.

Key Findings

More studies are required to determine the effect of omega 3 supplementations during pregnancy and the risk of detrimental fetal outcomes.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 37
Age Range See abstract
Condition See abstract

MeSH Terms

  • Adult
  • Dietary Supplements
  • Fatty Acids, Omega-3
  • Female
  • Humans
  • Incidence
  • Infant, Newborn
  • Maternal Nutritional Physiological Phenomena
  • Pregnancy
  • Premature Birth
  • Prenatal Care
  • Risk Factors

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: omega-3-pregnancy

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09