The Effects of Curcumin on Diabetes Mellitus: A Systematic Review

source extracted confidence: high 2026-04-09
#animals #anti-inflammatory-agents-non-steroidal #curcumin #diabetes-mellitus #humans

The Effects of Curcumin on Diabetes Mellitus: A Systematic Review

Marton et al., 2021 | Front Endocrinol (Lausanne) | Systematic Review

Citation

Marton Ledyane Taynara, Pescinini-E-Salzedas Laís Maria, ... Cincotto Dos Santos Bueno Patricia. The Effects of Curcumin on Diabetes Mellitus: A Systematic Review. Front Endocrinol (Lausanne). 2021;12:669448. doi:10.3389/fendo.2021.669448

Abstract

Diabetes mellitus (DM) is an ensemble of metabolic conditions that have reached pandemic proportions worldwide. Pathology's multifactorial nature makes patient management, including lifelong drug therapy and lifestyle modification, extremely challenging. Currently, there is growing evidence about the effectiveness of using herbal supplements in preventing and controlling DM. Curcumin is a bioactive component found Curcuma longa, which exhibits several physiological and pharmacological properties such as antioxidant, anti-inflammatory, anticancer, neuroprotective, and anti-diabetic activities. For these reasons, our objective is to systematically review the effects of Curcuma longa or curcumin on DM. Databases such as PUBMED and EMBASE were searched, and the final selection included sixteen studies that fulfilled the inclusion criteria. The results showed that curcumin's anti-diabetic activity might be due to its capacity to suppress oxidative stress and inflammatory process. Also, it significantly reduces fasting blood glucose, glycated hemoglobin, and body mass index. Nanocurcumin is also associated with a significant reduction in triglycerides, VLDL-c, total cholesterol, LDL-c, HDL-c, serum C reactive protein, and plasma malonaldehyde. Therefore, it can be considered in the therapeutic approach of patients with DM.

Key Findings

Therefore, it can be considered in the therapeutic approach of patients with DM.

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population dm
Sample Size See abstract
Age Range See abstract
Condition stress

MeSH Terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal
  • Curcumin
  • Diabetes Mellitus
  • Humans

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Systematic Review, Journal Article
  • Vertical: curcumin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09