The impact of resveratrol on skin wound healing, scarring, and aging

source extracted confidence: high 2026-04-09
#cicatrix #humans #research-design #resveratrol

The impact of resveratrol on skin wound healing, scarring, and aging

Hecker et al., 2022 | Int Wound J | Systematic Review

Citation

Hecker Andrzej, Schellnegger Marlies, ... Kotzbeck Petra. The impact of resveratrol on skin wound healing, scarring, and aging. Int Wound J. 2022-Jan;19(1):9-28. doi:10.1111/iwj.13601

Abstract

Resveratrol is a well-known antioxidant that harbours many health beneficial properties. Multiple studies associated the antioxidant, anti-inflammatory, and cell protective effects of resveratrol. These diverse effects of resveratrol are also potentially involved in cutaneous wound healing, scarring, and (photo-)aging of the skin. Hence, this review highlighted the most relevant studies involving resveratrol in wound healing, scarring, and photo-aging of the skin. A systematic review was performed and the database PubMed was searched for suitable publications. Only original articles in English that investigated the effects of resveratrol in wound healing, scarring, and (photo-)aging of the skin were analysed. The literature search yielded a total of 826 studies, but only 41 studies met the inclusion criteria. The included studies showed promising results that resveratrol might be a feasible treatment approach to support wound healing, counteract excessive scarring, and even prevent photo-aging of the skin. Resveratrol represents an interesting and promising novel therapy regime but to confirm resveratrol-associated effects, more evidence based in vitro and in vivo studies are needed.

Key Findings

Resveratrol represents an interesting and promising novel therapy regime but to confirm resveratrol-associated effects, more evidence based in vitro and in vivo studies are needed.

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population See abstract
Sample Size 826
Age Range See abstract
Condition See abstract

MeSH Terms

  • Cicatrix
  • Humans
  • Research Design
  • Resveratrol

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: resveratrol

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09