[Efficacy of curcumin in the treatment of oral submucous fibrosis: a Meta-analysis]

source extracted confidence: high 2026-04-09
#curcumin #databases-factual #humans #oral-submucous-fibrosis #randomized-controlled-trials-as-topic

[Efficacy of curcumin in the treatment of oral submucous fibrosis: a Meta-analysis]

Guo et al., 2021 | Hua Xi Kou Qiang Yi Xue Za Zhi | Meta Analysis

Citation

Guo Jin-Cai, Xie Hui, ... Tong Tie-Jun. [Efficacy of curcumin in the treatment of oral submucous fibrosis: a Meta-analysis]. Hua Xi Kou Qiang Yi Xue Za Zhi. 2021-Apr-01;39(2):195-202. doi:10.7518/hxkq.2021.02.011

Abstract

OBJECTIVES: This study was performed to review the efficacy of curcumin in the treatment of oral submucous fibrosis systematically. METHODS: We searched seven databases, including Web of Science, PubMed, EBSCO, The Cochrane Library, CNKI, WanFang Data, and VIP, to obtain randomized controlled trials related to the treatment of oral submucous fibrosis by curcumin. Each database was searched from inception to 30 June 2019. RevMan 5.3 software was used for the meta-analysis. RESULTS: Six randomized controlled trials involving 350 patients were included in this study. Meta-analysis showed that curcumin can increase the maximal mouth opening and improve burning sensation compared with placebo treatment. Curcumin was not as effective as the controls in achieving maximal mouth opening after 1 month of treatment. However, no statistically significant difference was observed between the treatments from 2 months to 6 months. Curcumin significantly improved burning sensation compared with the controls after 3 months of treatment. No statistically significant diffe-rence in burning sensation was observed between the curcumin and control groups after 1, 2, and 6 months of treatment. CONCLUSIONS: The current evidence shows that curcumin is an effective treatment for improving maximal mouth opening and burning sensation in patients with oral submucous fibrosis. Given the limited number and low quality of the included studies, however, more high-quality studies are needed to verify these findings.

Key Findings

Six randomized controlled trials involving 350 patients were included in this study. Meta-analysis showed that curcumin can increase the maximal mouth opening and improve burning sensation compared with placebo treatment. Curcumin was not as effective as the controls in achieving maximal mouth opening after 1 month of treatment. However, no statistically significant difference was observed between the treatments from 2 months to 6 months. Curcumin significantly improved burning sensation compare

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population oral submucous fibrosis
Sample Size 350
Age Range See abstract
Condition See abstract

MeSH Terms

  • Curcumin
  • Databases, Factual
  • Humans
  • Oral Submucous Fibrosis
  • Randomized Controlled Trials as Topic
  • Treatment Outcome

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis
  • Vertical: curcumin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09