Systematic review and meta-analysis of randomised, controlled trials on the effects of garlic supplementation on serum adiponectin and leptin levels

source extracted confidence: high 2026-04-09
#adiponectin #adult #antioxidants #dietary-supplements #garlic

Systematic review and meta-analysis of randomised, controlled trials on the effects of garlic supplementation on serum adiponectin and leptin levels

Shekarchizadeh-Esfahani et al., 2021 | Int J Clin Pract | Meta Analysis

Citation

Shekarchizadeh-Esfahani Parivash, Hassani Bahar, ... Sorraya Nasim. Systematic review and meta-analysis of randomised, controlled trials on the effects of garlic supplementation on serum adiponectin and leptin levels. Int J Clin Pract. 2021-Oct;75(10):e14200. doi:10.1111/ijcp.14200

Abstract

BACKGROUND: Our aim in this meta-analysis was to determine the effect of garlic supplementation on adiponectin and leptin serum levels. METHOD: A systematic search was conducted using PubMed, Scopus, ISI Web of Science and Cochrane Library for eligible trials up to November 2020. A fixed-effects model was used to pool calculated effect sizes. RESULTS: Five trials were included in the overall analysis. Our analysis showed that garlic supplementation did not significantly affect adiponectin (Hedges's: 0.20; 95% CI: -0.06, 0.47; P-values = .12) and leptin (Hedges's: 0.08; 95% CI: -0.26, 0.41; P-values = .65) concentrations in comparison with placebo. However, in the subgroup analysis, significantly increased serum adiponectin level was seen following garlic supplementation in trials with a mean age of participants ˂30 years (Hedges's: 0.44; 95% CI: 0.01, 0.87; P-values = .04), the doses ˂1.5 g/d (Hedges's: 0.38; 95% CI: 0.02, 0.71; P-values = .04) and trials with duration ≥8 weeks (Hedges's: 0.48; 95% CI: 0.08, 0.89; P-values = .02). CONCLUSION: Overall, garlic supplementation could not change the circulatory adiponectin and leptin levels. Subgroup analyses showed a significant reduction in adiponectin levels in younger participants, longer duration and lower intervention dose. However, further studies are needed to confirm the present results.

Key Findings

Five trials were included in the overall analysis. Our analysis showed that garlic supplementation did not significantly affect adiponectin (Hedges's: 0.20; 95% CI: -0.06, 0.47; P-values = .12) and leptin (Hedges's: 0.08; 95% CI: -0.26, 0.41; P-values = .65) concentrations in comparison with placebo. However, in the subgroup analysis, significantly increased serum adiponectin level was seen following garlic supplementation in trials with a mean age of participants ˂30 years (Hedges's: 0.44; 95%

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Adiponectin
  • Adult
  • Antioxidants
  • Dietary Supplements
  • Garlic
  • Humans
  • Leptin
  • Randomized Controlled Trials as Topic

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Meta-Analysis, Systematic Review, Journal Article
  • Vertical: garlic

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09