Anticancer Effects of Ginsenoside Rh2: A Systematic Review

He et al., 2022 | Curr Mol Pharmacol | Systematic Review

Citation

He Xin-Ling, Xu Xiao-Huang, ... Lu Jin-Jian. Anticancer Effects of Ginsenoside Rh2: A Systematic Review. Curr Mol Pharmacol. 2022;15(1):179-189. doi:10.2174/1874467214666210309115105

Abstract

BACKGROUND: As one of the effective pharmacological constituents of Ginseng Radix et Rhizoma, ginsenoside Rh2 (Rh2) exerts a remarkable anticancer effect on various cancer cell lines in vitro and strongly inhibits tumor growth in vivo without severe toxicity. OBJECTIVE: This article reviewed existing evidence supporting the anticancer effects of Rh2 to classify and conclude previous and current knowledge on the mechanisms and therapeutic effects of Rh2, as well as to promote the clinical application of this natural product. CONCLUSION: This article reviewed the anticancer efficacies and mechanisms of Rh2, including the induction of cell cycle arrest and programmed cell death, repression of metastasis, alleviation of drug resistance, and regulation of the immune system. Finally, this paper discussed the research and application prospects of Rh2.

Key Findings

This article reviewed the anticancer efficacies and mechanisms of Rh2, including the induction of cell cycle arrest and programmed cell death, repression of metastasis, alleviation of drug resistance, and regulation of the immune system. Finally, this paper discussed the research and application prospects of Rh2.

Outcomes Measured

• Requires manual extraction

Population

MeSH Terms

• Apoptosis
• Cell Cycle Checkpoints
• Ginsenosides
• Panax

Evidence Classification

• Level: Systematic Review
• Publication Types: Journal Article, Research Support, Non-U.S. Gov't, Systematic Review
• Vertical: ginseng

Provenance

• PMID: 33687905
• DOI: 10.2174/1874467214666210309115105
• PMCID: Not in PMC
• Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09