Systematic Review of Nutrition Supplements in Chronic Kidney Diseases: A GRADE Approach

source extracted confidence: high 2026-04-09
#dietary-supplements #humans #nutrition-therapy #renal-insufficiency-chronic

Systematic Review of Nutrition Supplements in Chronic Kidney Diseases: A GRADE Approach

Lin et al., 2021 | Nutrients | Systematic Review

Citation

Lin Pei-Chin, Chou Chu-Lin, ... Chen Jin-Shuen. Systematic Review of Nutrition Supplements in Chronic Kidney Diseases: A GRADE Approach. Nutrients. 2021-Jan-30;13(2). doi:10.3390/nu13020469

Abstract

Chronic kidney disease (CKD) is cumulative worldwide and an increasing public health issue. Aside from the widely known protein restriction and medical therapy, less evident is the renal protection of nutrition supplements in CKD patients. This systematic review (SR), using a Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach, aims to summarize and quantify evidence about the prevention effects of vitamin D and analogues, omega-3 polyunsaturated fatty acid (omega-3 PUFA), dietary fiber, coenzyme Q10 (CoQ10), and biotics on CKD progression. This study was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement to examine SRs and/or meta-analysis of clinical controlled trials identified from PubMed, Embase, and the Cochrane Library. Finally, seventeen SRs were included in the qualitative analysis. The beneficial effects of these nutrition supplements in CKD patients mostly seem to be at low to very low evidence on proteinuria, kidney function, and inflammations and did not appear to improve CKD prognosis. The recommendation of nutrition supplements in CKD patients needs to discuss with physicians and consider the benefits over the adverse effects. Longer follow-up of larger randomized trials is necessary to clarify the benefits of nutrition supplements in CKD patients.

Key Findings

Longer follow-up of larger randomized trials is necessary to clarify the benefits of nutrition supplements in CKD patients.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition inflammation

MeSH Terms

  • Dietary Supplements
  • Humans
  • Nutrition Therapy
  • Renal Insufficiency, Chronic

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: coq10

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09