Functional foods modulating inflammation and metabolism in chronic diseases: a systematic review

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#animals #chronic-disease #diet #functional-food #humans

Functional foods modulating inflammation and metabolism in chronic diseases: a systematic review

Luvián-Morales et al., 2022 | Crit Rev Food Sci Nutr | Systematic Review

Citation

Luvián-Morales Julissa, Varela-Castillo Francisco Omar, ... Castro-Eguiluz Denisse. Functional foods modulating inflammation and metabolism in chronic diseases: a systematic review. Crit Rev Food Sci Nutr. 2022;62(16):4371-4392. doi:10.1080/10408398.2021.1875189

Abstract

Chronic diseases are responsible for approximately 71% global deaths. These are characterized by chronic low-grade inflammation and metabolic alterations. "Functional foods" have been attributed with anti-inflammatory properties, demonstrated in cell lines and murine models; however, studies in humans are inconclusive. The purpose of this systematic review is to identify clinical trials that analyzed changes in inflammatory and metabolic mediators, in response to consumption of specific functional foods. A total of 3581 trials were screened and 88 were included for this review. Foods identified to regulate inflammation included cranberries, grapes, pomegranate, strawberries, wheat, whole grain products, low fat dairy products, yogurt, green tea, cardamom, turmeric, soy foods, almonds, chia seeds, flaxseed, pistachios, algae oil, flaxseed oil and grape seed oil. Clinical trials that focus on a dietary pattern rich in functional foods are necessary to explore if the additive effect of these foods lead to more clinically relevant outcomes.

Key Findings

Clinical trials that focus on a dietary pattern rich in functional foods are necessary to explore if the additive effect of these foods lead to more clinically relevant outcomes.

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population See abstract
Sample Size 3581
Age Range See abstract
Condition inflammation

MeSH Terms

  • Animals
  • Chronic Disease
  • Diet
  • Functional Food
  • Humans
  • Inflammation
  • Linseed Oil
  • Mice

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: curcumin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09