Could Vitamins Help in the Fight Against COVID-19?

source extracted confidence: high 2026-04-09
#antioxidants #ascorbic-acid #betacoronavirus #covid-19 #coronavirus-infections

Could Vitamins Help in the Fight Against COVID-19?

Jovic et al., 2020 | Nutrients | Systematic Review

Citation

Jovic Thomas H, Ali Stephen R, ... Whitaker Iain S. Could Vitamins Help in the Fight Against COVID-19?. Nutrients. 2020-Aug-23;12(9). doi:10.3390/nu12092550

Abstract

There are limited proven therapeutic options for the prevention and treatment of COVID-19. The role of vitamin and mineral supplementation or "immunonutrition" has previously been explored in a number of clinical trials in intensive care settings, and there are several hypotheses to support their routine use. The aim of this narrative review was to investigate whether vitamin supplementation is beneficial in COVID-19. A systematic search strategy with a narrative literature summary was designed, using the Medline, EMBASE, Cochrane Trials Register, WHO International Clinical Trial Registry, and Nexis media databases. The immune-mediating, antioxidant and antimicrobial roles of vitamins A to E were explored and their potential role in the fight against COVID-19 was evaluated. The major topics extracted for narrative synthesis were physiological and immunological roles of each vitamin, their role in respiratory infections, acute respiratory distress syndrome (ARDS), and COVID-19. Vitamins A to E highlighted potentially beneficial roles in the fight against COVID-19 via antioxidant effects, immunomodulation, enhancing natural barriers, and local paracrine signaling. Level 1 and 2 evidence supports the use of thiamine, vitamin C, and vitamin D in COVID-like respiratory diseases, ARDS, and sepsis. Although there are currently no published clinical trials due to the novelty of SARS-CoV-2 infection, there is pathophysiologic rationale for exploring the use of vitamins in this global pandemic, supported by early anecdotal reports from international groups. The final outcomes of ongoing trials of vitamin supplementation are awaited with interest.

Key Findings

The final outcomes of ongoing trials of vitamin supplementation are awaited with interest.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition stress

MeSH Terms

  • Antioxidants
  • Ascorbic Acid
  • Betacoronavirus
  • COVID-19
  • Coronavirus Infections
  • Dietary Supplements
  • Humans
  • Pandemics
  • Pneumonia, Viral
  • SARS-CoV-2
  • Thiamine
  • Vitamin A
  • Vitamin D
  • Vitamin E
  • Vitamins
  • COVID-19 Drug Treatment

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: thiamine

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09