The effect and safety of Berberine on polycystic ovary syndrome: a systematic review
The effect and safety of Berberine on polycystic ovary syndrome: a systematic review
Mirzaee et al., 2021 | J Obstet Gynaecol | Systematic Review
Citation
Mirzaee Firoozeh, Razmjouei Parisa, ... Ghazanfarpour Masumeh. The effect and safety of Berberine on polycystic ovary syndrome: a systematic review. J Obstet Gynaecol. 2021-Jul;41(5):684-689. doi:10.1080/01443615.2020.1787964
Abstract
The aim of this systematic review is to assess the effect of Berberine (BBR) on women's health to provide greater insights about its effect on women with polycystic syndrome for both patients and health care providers. Electronic databases such as PubMed, Web of Science, Scopus, Cochrane Central Register of Controlled Trials (CENTRAL) were systematically searched from the base to July 1th, 2019 to identify clinical trials and randomised controlled trials that had explored the effect of BBR on the polycystic syndrome. With regard to the weight and composition body, BBR did not have any significant effect on reducing body weight and conflicting findings had been reported about waist circumference (WC) and body mass index (BMI). However, BBR led to a significant decrease in waist to hip ratio (WHR), profile hormonal insulin resistance (IR), and insulin resistance (HOMA-IR). Further, androstenedione dropped significantly following treatment with BBB. However, BBB did not have a significant effect on follicle stimulating hormone (FSH) and luteinizing hormone (LH).
Key Findings
However, BBB did not have a significant effect on follicle stimulating hormone (FSH) and luteinizing hormone (LH).
Outcomes Measured
- Requires manual extraction
Population
| Field | Value |
|---|---|
| Population | See abstract |
| Sample Size | See abstract |
| Age Range | See abstract |
| Condition | See abstract |
MeSH Terms
- Adult
- Androstenedione
- Berberine
- Body Mass Index
- Female
- Follicle Stimulating Hormone
- Humans
- Insulin
- Insulin Resistance
- Luteinizing Hormone
- Polycystic Ovary Syndrome
- Treatment Outcome
- Waist Circumference
- Waist-Hip Ratio
Evidence Classification
- Level: Systematic Review
- Publication Types: Journal Article, Systematic Review
- Vertical: berberine
Provenance
- PMID: 32811221
- DOI: 10.1080/01443615.2020.1787964
- PMCID: Not in PMC
- Verified: 2026-04-09 via PubMed E-utilities API
Source extracted via PubMed E-utilities API on 2026-04-09