Probiotic Supplementation During the Perinatal and Infant Period: Effects on Gut Dysbiosis and Disease

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#dysbiosis #enterocolitis-necrotizing #female #gastrointestinal-microbiome #humans

Probiotic Supplementation During the Perinatal and Infant Period: Effects on Gut Dysbiosis and Disease

Navarro-Tapia et al., 2020 | Nutrients | Systematic Review

Citation

Navarro-Tapia Elisabet, Sebastiani Giorgia, ... Andreu-Fernández Vicente. Probiotic Supplementation During the Perinatal and Infant Period: Effects on Gut Dysbiosis and Disease. Nutrients. 2020-Jul-27;12(8). doi:10.3390/nu12082243

Abstract

The perinatal period is crucial to the establishment of lifelong gut microbiota. The abundance and composition of microbiota can be altered by several factors such as preterm delivery, formula feeding, infections, antibiotic treatment, and lifestyle during pregnancy. Gut dysbiosis affects the development of innate and adaptive immune responses and resistance to pathogens, promoting atopic diseases, food sensitization, and infections such as necrotizing enterocolitis (NEC). Recent studies have indicated that the gut microbiota imbalance can be restored after a single or multi-strain probiotic supplementation, especially mixtures of Lactobacillus and Bifidobacterium strains. Following the systematic search methodology, the current review addresses the importance of probiotics as a preventive or therapeutic tool for dysbiosis produced during the perinatal and infant period. We also discuss the safety of the use of probiotics in pregnant women, preterm neonates, or infants for the treatment of atopic diseases and infections.

Key Findings

We also discuss the safety of the use of probiotics in pregnant women, preterm neonates, or infants for the treatment of atopic diseases and infections.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population pregnant women
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Dysbiosis
  • Enterocolitis, Necrotizing
  • Female
  • Gastrointestinal Microbiome
  • Humans
  • Infant
  • Infant, Newborn
  • Infant, Newborn, Diseases
  • Male
  • Perinatal Care
  • Probiotics

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: probiotics

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09