Effects of garlic supplementation on serum inflammatory markers: A systematic review and meta-analysis of randomized controlled trials
Effects of garlic supplementation on serum inflammatory markers: A systematic review and meta-analysis of randomized controlled trials
Mirzavandi et al., 2020 | Diabetes Metab Syndr | Meta Analysis
Citation
Mirzavandi Farhang, Mollahosseini Mehdi, ... Mozaffari-Khosravi Hassan. Effects of garlic supplementation on serum inflammatory markers: A systematic review and meta-analysis of randomized controlled trials. Diabetes Metab Syndr. 2020;14(5):1153-1161. doi:10.1016/j.dsx.2020.06.031
Abstract
BACKGROUND AND AIMS: Previous studies have indicated that garlic consumption may be beneficial in improving inflammation. This systematic review and meta-analysis aimed to examine the effect of garlic supplementation on inflammatory biomarkers. METHODS: PubMed/Medline, Scopus and ISI web of science were searched up to February 2019. Random effects model was used to calculate the overall effects on C-reactive protein (CRP), Interleukin-6 (IL-6), and Tumor necrosis factor- α (TNF-α). RESULTS: 17 randomized controlled trials (RCTs) were included in the meta-analyses. Garlic supplementation significantly reduced the level of circulating CRP (P < 0.05), whereas it did not have any significant effect on IL-6 level (p > 0.05). Sub-group analysis showed that aged garlic extract (AGE) was able to reduce CRP and TNF-α significantly (P < 0.05). CONCLUSIONS: This meta-analysis showed that supplementation with garlic could reduce the level of circulating CRP and AGE could reduce the level of TNF-α and CRP, whereas it had no significant effect on the IL-6 level.
Key Findings
17 randomized controlled trials (RCTs) were included in the meta-analyses. Garlic supplementation significantly reduced the level of circulating CRP (P < 0.05), whereas it did not have any significant effect on IL-6 level (p > 0.05). Sub-group analysis showed that aged garlic extract (AGE) was able to reduce CRP and TNF-α significantly (P < 0.05).
Outcomes Measured
- C-reactive protein
- inflammatory markers
Population
| Field | Value |
|---|---|
| Population | See abstract |
| Sample Size | See abstract |
| Age Range | See abstract |
| Condition | inflammation |
MeSH Terms
- Dietary Supplements
- Garlic
- Humans
- Inflammation
- Inflammation Mediators
- Prognosis
- Randomized Controlled Trials as Topic
Evidence Classification
- Level: Meta Analysis
- Publication Types: Journal Article, Meta-Analysis, Systematic Review
- Vertical: garlic
Provenance
- PMID: 32673835
- DOI: 10.1016/j.dsx.2020.06.031
- PMCID: Not in PMC
- Verified: 2026-04-09 via PubMed E-utilities API
Source extracted via PubMed E-utilities API on 2026-04-09