Selenium Level in Patients with Vitiligo: A Meta-Analysis

source extracted confidence: high 2026-04-09
#adolescent #adult #aged #aged-80-and-over #asian-people

Selenium Level in Patients with Vitiligo: A Meta-Analysis

Dai et al., 2020 | Biomed Res Int | Meta Analysis

Citation

Dai Ting, Xiaoying Sun, ... Bo Liang. Selenium Level in Patients with Vitiligo: A Meta-Analysis. Biomed Res Int. 2020;2020:7580939. doi:10.1155/2020/7580939

Abstract

BACKGROUND: It has been reported that deficiency of selenium can cause autoimmune disease. This meta-analysis was aimed at evaluating whether there exits an association between selenium level and vitiligo. METHODS: A comprehensive search was conducted on PubMed, Embase, China National Knowledge Infrastructure (CNKI), Wanfang Med Online, and China VIP databases from the inception to February 12, 2019. The main outcome was the standardized mean difference (SMD) with 95% confidence interval (CI) in serum selenium level between vitiligo patients and healthy controls. RESULTS: A total of 8 studies with 305 vitiligo patients and 6156 healthy controls were included in this meta-analysis. The results showed that there was no significant difference in selenium level between vitiligo patients and healthy controls (SMD = 0.481, 95%CI = -0.642 to 1.604, Z = 0.840, P > 0.05). Further subgroup analysis stratified by area revealed that Asian vitiligo patients had decreased selenium level, while that finding was not observed in Caucasian patients (Asian: SMD = -0.303, 95%CI = -0.603 to -0.004, P < 0.05; Caucasian: SMD = 0.957, 95%CI = -0.752 to 2.665, P > 0.05). CONCLUSIONS: Although overall selenium level was similar between vitiligo patients and health controls, subgroup analysis showed decreased levels of selenium in Asian vitiligo patients. It may suggest a clinical tailored administration of selenium supplementation in Asian vitiligo patients.

Key Findings

A total of 8 studies with 305 vitiligo patients and 6156 healthy controls were included in this meta-analysis. The results showed that there was no significant difference in selenium level between vitiligo patients and healthy controls (SMD = 0.481, 95%CI = -0.642 to 1.604, Z = 0.840, P > 0.05). Further subgroup analysis stratified by area revealed that Asian vitiligo patients had decreased selenium level, while that finding was not observed in Caucasian patients (Asian: SMD = -0.303, 95%CI = -0

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 8
Age Range See abstract
Condition deficiency

MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Asian People
  • Child
  • Humans
  • Middle Aged
  • Selenium
  • Vitiligo
  • White People
  • Young Adult

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Review
  • Vertical: selenium

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09