Benefits and harms of ginseng supplementation on liver function? A systematic review and meta-analysis

source extracted confidence: high 2026-04-09
#adult #aged #aged-80-and-over #alanine-transaminase #alkaline-phosphatase

Benefits and harms of ginseng supplementation on liver function? A systematic review and meta-analysis

Ghavami et al., 2020 | Complement Ther Clin Pract | Meta Analysis

Citation

Ghavami Abed, Ziaei Rahele, ... Amani Reza. Benefits and harms of ginseng supplementation on liver function? A systematic review and meta-analysis. Complement Ther Clin Pract. 2020-May;39:101173. doi:10.1016/j.ctcp.2020.101173

Abstract

OBJECTIVE: Existing evidence on the possible effects of ginseng on liver function has not been fully established. Therefore, the present review was undertaken to evaluate the overall effects of ginseng supplementation on liver enzymes in adults. METHODS: A systematic computerized literature search of PubMed, Scopus, Web of Science, Cochrane Library and Google scholar databases was conducted up to May 2019. All RCTs using ginseng supplements in adults were included in this systematic review and meta-analysis. RESULTS: Overall, 14 randomized trials (with 20 arms) including 992 subjects were identified. Pooled analysis did not illustrate any significant changes in alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), and albumin (ALB) levels, however, it showed a minor significant increase in bilirubin (BIL) levels. Subgroup analysis by dosage and study population revealed significant increase of bilirubin after ginseng supplementation ≥3 g/day or in unhealthy individuals. CONCLUSION: Ginseng appears to have neither hepatoprotective nor hepatotoxic effects in conventional doses and duration. It is noteworthy that this seems applicable only for individuals with healthy liver function. Further largescale studies are warranted to confirm present findings.

Key Findings

Overall, 14 randomized trials (with 20 arms) including 992 subjects were identified. Pooled analysis did not illustrate any significant changes in alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), and albumin (ALB) levels, however, it showed a minor significant increase in bilirubin (BIL) levels. Subgroup analysis by dosage and study population revealed significant increase of bilirubin after ginseng supplementation ≥3

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population healthy liver function
Sample Size 992
Age Range See abstract
Condition See abstract

MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alanine Transaminase
  • Alkaline Phosphatase
  • Aspartate Aminotransferases
  • Bilirubin
  • Complementary Therapies
  • Dietary Supplements
  • Female
  • Humans
  • Liver
  • Liver Function Tests
  • Male
  • Middle Aged
  • Panax
  • Plant Exudates
  • gamma-Glutamyltransferase

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: ginseng

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09