The Pharmacological Activity of Camellia sinensis (‎L.‎) ‎Kuntze‎ on Metabolic and Endocrine Disorders: A Systematic Review

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#camellia-sinensis #clinical-trials-as-topic #endocrine-system-diseases #humans #metabolic-diseases

The Pharmacological Activity of Camellia sinensis (‎L.‎) ‎Kuntze‎ on Metabolic and Endocrine Disorders: A Systematic Review

Sánchez et al., 2020 | Biomolecules | Systematic Review

Citation

Sánchez Marta, González-Burgos Elena, ... Gómez-Serranillos M Pilar. The Pharmacological Activity of Camellia sinensis (‎L.‎) ‎Kuntze‎ on Metabolic and Endocrine Disorders: A Systematic Review. Biomolecules. 2020-Apr-13;10(4). doi:10.3390/biom10040603

Abstract

Tea made from Camellia sinensis leaves is one of the most consumed beverages worldwide. This systematic review aims to update Camellia sinensis pharmacological activity on metabolic and endocrine disorders. Inclusion criteria were preclinical and clinical studies of tea extracts and isolated compounds on osteoporosis, hypertension, diabetes, metabolic syndrome, hypercholesterolemia, and obesity written in English between 2014 and 2019 and published in Pubmed, Science Direct, and Scopus. From a total of 1384 studies, 80 reports met inclusion criteria. Most papers were published in 2015 (29.3%) and 2017 (20.6%), conducted in China (28.75%), US (12.5%), and South Korea (10%) and carried out with extracts (67.5%, especially green tea) and isolated compounds (41.25%, especially epigallocatechin gallate). Most pharmacological studies were in vitro and in vivo studies focused on diabetes and obesity. Clinical trials, although they have demonstrated promising results, are very limited. Future research should be aimed at providing more clinical evidence on less studied pathologies such as osteoporosis, hypertension, and metabolic syndrome. Given the close relationship among all endocrine disorders, it would be of interest to find a standard dose of tea or their bioactive constituents that would be beneficial for all of them.

Key Findings

Given the close relationship among all endocrine disorders, it would be of interest to find a standard dose of tea or their bioactive constituents that would be beneficial for all of them.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 1384
Age Range See abstract
Condition hypertension

MeSH Terms

  • Camellia sinensis
  • Clinical Trials as Topic
  • Endocrine System Diseases
  • Humans
  • Metabolic Diseases

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: green-tea

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09