Ginkgo leaf extract and dipyridamole injection for chronic cor pulmonale: a PRISMA-compliant meta-analysis of randomized controlled trials

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#cardiovascular-diseases #chronic-disease #dipyridamole #drugs-chinese-herbal #ginkgo-biloba

Ginkgo leaf extract and dipyridamole injection for chronic cor pulmonale: a PRISMA-compliant meta-analysis of randomized controlled trials

Qiu et al., 2020 | Biosci Rep | Meta Analysis

Citation

Qiu Jian, Guo Yijun, ... Yang Yapei. Ginkgo leaf extract and dipyridamole injection for chronic cor pulmonale: a PRISMA-compliant meta-analysis of randomized controlled trials. Biosci Rep. 2020-Mar-27;40(3). doi:10.1042/BSR20200099

Abstract

Ginkgo leaf extract and dipyridamole injection (GLED), a kind of Chinese herbal medicine preparation, has been considered as a promising supplementary treatment for chronic cor pulmonale (CCP). Although an analysis of the published literature has been performed, the exact effects and safety of GLED have yet to be systematically investigated. Therefore, a wide-ranging systematic search of electronic databases from which to draw conclusions was conducted. All randomized controlled trials concerning the GLED plus conventional treatments for CCP were selected in the present study. Main outcomes were treatment efficacy, blood gas and hemorrheology indexes, and adverse events. Data from 28 trials with 2457 CCP patients were analyzed. The results indicated that, compared with conventional treatments alone, the combination of conventional treatments with GLED obviously improved the markedly effective rate (RR = 1.44, 95% CI = 1.31-1.58, P < 0.00001) and total effective rate (RR = 1.28, 95% CI = 1.18-1.38, P < 0.00001). Moreover, the hemorrheology (PaO2, P < 0.00001; PaCO2, P < 0.00001; SaO2, P < 0.00001; pH value, P = 0.05) and blood gas indexes (PV, WBHSV, WBMSV, WBLSV, hematocrit and FBG, P < 0.01) of CCP patients were also significantly ameliorated after the combined therapy. The frequency of adverse events did not differ significantly between the two groups (P > 0.05). In summary, evidence from the meta-analysis suggested that the combination of conventional treatments and GLED appeared to be effective and relatively safe for CCP. Therefore, GLED mediated therapy could be recommended as an adjuvant treatment for CCP.

Key Findings

Therefore, GLED mediated therapy could be recommended as an adjuvant treatment for CCP.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 28
Age Range See abstract
Condition See abstract

MeSH Terms

  • Cardiovascular Diseases
  • Chronic Disease
  • Dipyridamole
  • Drugs, Chinese Herbal
  • Ginkgo biloba
  • Humans
  • Hypertension, Pulmonary
  • Plant Extracts
  • Pulmonary Heart Disease
  • Randomized Controlled Trials as Topic
  • Treatment Outcome
  • Ginkgo Extract

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't
  • Vertical: ginkgo

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09