Liver function monitoring: a prospective nested case-control study of Salvia miltiorrhiza polyphenol injection

source extracted confidence: high 2026-04-09
#adolescent #adult #aged #aged-80-and-over #female

Liver function monitoring: a prospective nested case-control study of Salvia miltiorrhiza polyphenol injection

Cheng et al., 2020 | Sci Rep | Meta Analysis

Citation

Cheng Jin-Quan, Shi Qing-Ping, ... Wang Can. Liver function monitoring: a prospective nested case-control study of Salvia miltiorrhiza polyphenol injection. Sci Rep. 2020-Feb-26;10(1):3538. doi:10.1038/s41598-020-60608-z

Abstract

Instructions for Salvia miltiorrhiza polyphenol injections indicate abnormal liver function as an occasional adverse reaction, but the incidence of this adverse drug reaction (ADR) has increased in recent years. We assessed S. miltiorrhiza polyphenol ADRs by performing a nested case-control study(NCCS) and meta-analysis. In the NCCS, 2633 patients receiving this treatment in the First Affiliated Hospital of Bengbu Medical College were enrolled. Logistic regression models found that in 58 (2.2%) patients experiencing abnormal liver function, the risk for liver dysfunction was associated with sulfa drug allergy (OR = 7.874, 95%CI (1.280, 48.447), P = 0.026), payment methods (OR = 0.106, 95%CI (0.012, 0.934), P = 0.043), duration of administration (OR = 0.922, 95%CI (0.862, 0.986), P = 0.017), cefathiamidine (OR = 0.441, 95%CI (0.216, 0.900), P = 0.025), human serum albumin (OR = 1.958, 95%CI (1.011, 3.789), P = 0.046), Dazhu Rhodiola injection (OR = 2.599, 95%CI (1.112, 6.070), P = 0.027), or reduced glutathione (OR = 0.394, 95%CI (0.188, 0.826), P = 0.014). Meta-analysis of reports on S. miltiorrhiza polyphenol ADRs in controlled trials and other observational studies included 676 patients, of which 17 (2.17%; 95%CI (0.0105, 0.0358)) presented with liver dysfunction; associated ADR risk factors included co-administration of other drugs. Our NCCS and meta-analysis had similar ADR incidence rates, which were higher than the rate in the drug instructions. This study provides guidance for assessing liver dysfunction risks associated with S. miltiorrhiza polyphenol injections.

Key Findings

miltiorrhiza polyphenol injections.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 2633
Age Range See abstract
Condition See abstract

MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Male
  • Middle Aged
  • Case-Control Studies
  • Drug Monitoring
  • Liver
  • Observational Studies as Topic
  • Polyphenols
  • Salvia miltiorrhiza
  • Controlled Clinical Trials as Topic

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't
  • Vertical: rhodiola

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09