Possible Involvement of Vitamin C in Periodontal Disease-Diabetes Mellitus Association

source extracted confidence: high 2026-04-09
#ascorbic-acid #clinical-trials-as-topic #diabetes-complications #dietary-supplements #humans

Possible Involvement of Vitamin C in Periodontal Disease-Diabetes Mellitus Association

Bogdan et al., 2020 | Nutrients | Systematic Review

Citation

Bogdan Maria, Meca Andreea Daniela, ... Surlin Petra. Possible Involvement of Vitamin C in Periodontal Disease-Diabetes Mellitus Association. Nutrients. 2020-Feb-20;12(2). doi:10.3390/nu12020553

Abstract

Ascorbic acid (vitamin C) is an important water-soluble vitamin found in many fruits and vegetables. It has well-documented beneficial effects on the human body and is used as a supplement, alone or in combination with other vitamins and minerals. Over recent years, research has focused on possible new therapeutic actions in chronic conditions including periodontal disease (PD). We conducted a systematic review on clinical trials from four databases (PubMed, Clinical Trials, Cochrane, Web of Science) which measured plasmatic/salivary levels of ascorbic acid in PD-diabetes mellitus (DM) association. Six studies were included in our review, three of them analyzing patients with different grades of PD and DM who received vitamin C as a treatment (500 mg vitamin C/day for 2 months and 450 mg/day for 2 weeks) or as part of their alimentation (guava fruits), in combination with standard therapies and procedures. Decreased levels of vitamin C were observed in PD patients with DM but data about efficacy of vitamin C administration are inconclusive. Given the important bidirectional relationship between PD and DM, there is a strong need for more research to assess the positive effects of ascorbic acid supplementation in individuals suffering from both diseases and also its proper regimen for these patients.

Key Findings

Given the important bidirectional relationship between PD and DM, there is a strong need for more research to assess the positive effects of ascorbic acid supplementation in individuals suffering from both diseases and also its proper regimen for these patients.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population different grades of pd
Sample Size See abstract
Age Range See abstract
Condition diabetes

MeSH Terms

  • Ascorbic Acid
  • Clinical Trials as Topic
  • Diabetes Complications
  • Dietary Supplements
  • Humans
  • Periodontal Diseases
  • Plasma
  • Saliva
  • Vitamins

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: vitamin-c

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09