Anti-inflammatory and antioxidant therapies for chagasic myocarditis: a systematic review

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#anti-inflammatory-agents #antioxidants #chagas-cardiomyopathy #humans

Anti-inflammatory and antioxidant therapies for chagasic myocarditis: a systematic review

Freitas et al., 2020 | Parasitology | Systematic Review

Citation

Freitas Dayanne S, Silva Godinho Andressa S, ... Silva Lucilene A. Anti-inflammatory and antioxidant therapies for chagasic myocarditis: a systematic review. Parasitology. 2020-May;147(6):603-610. doi:10.1017/S0031182020000153

Abstract

The aim of this review was to identify anti-inflammatory and antioxidant therapeutic agents and their effects on patients with chagasic myocarditis. A systematic review of the MEDLINE, EMBASE, WEB OF SCIENCE, SCOPUS, LILACS and CENTRAL databases (Cochrane Library) was carried out without language restrictions. The descriptors used were: 'Chagas cardiomyopathy', 'treatment', 'Chagas disease', 'anti-inflammatory agents', 'Trypanosoma cruzi' and 'antioxidants'. A total of 4,138 articles was identified, six of which were selected for data extraction. Of these, four were related to antioxidant therapy with vitamins C and E supplementation, and two using anti-inflammatory therapy. The studies were carried out in Brazil and were published between 2002 and 2017. Antioxidant therapy with vitamin C and E supplementation increases the activity of antioxidant enzymes and reduces the oxidative markers. There is no conclusive data to support the use of vitamin supplementation and anti-inflammatory therapy in the treatment of chagasic cardiomyopathy. However, the studies indicate the possibility of vitamin supplementation as a new approach to the treatment of Chagas disease. Antioxidant therapy was proven to be a viable alternative for attenuating the oxidative damage caused by chronic chagasic cardiopathy, leading to a better prognosis for patients.

Key Findings

Antioxidant therapy was proven to be a viable alternative for attenuating the oxidative damage caused by chronic chagasic cardiopathy, leading to a better prognosis for patients.

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population chagasic myocarditis
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Anti-Inflammatory Agents
  • Antioxidants
  • Chagas Cardiomyopathy
  • Humans

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: vitamin-c

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09