[The role of resveratrol on heavy metal-induced oxidative stress]

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#antioxidants #cadmium #copper #heavy-metal-poisoning #humans

[The role of resveratrol on heavy metal-induced oxidative stress]

Nicolás-Méndez et al., 2020 | Nutr Hosp | Systematic Review

Citation

Nicolás-Méndez Tonancy, Ortiz-Muñiz Alda Rocío, ... García-Rodríguez María Del Carmen. [The role of resveratrol on heavy metal-induced oxidative stress]. Nutr Hosp. 2020-Apr-16;37(2):374-383. doi:10.20960/nh.02846

Abstract

Introduction and objetives: oxidative stress is considered one of the main mechanisms of genotoxicity and carcinogenicity of heavy metals. In contrast, resveratrol has antioxidant properties and is one of the most studied polyphenols due to its wide variety of beneficial health effects. However, there are no systematic reviews of the scientific literature in which the effects of resveratrol on oxidative stress induced by heavy metals are analyzed. Methods: in this review, articles were searched using the PubMed and ScienceDirect databases (1996-2018). After applying various filters, eleven in vivo and in vitro researches were considered, in which the effects of resveratrol on oxidative stress induced by arsenic (As), cadmium (Cd), copper (Cu), chromium (Cr) and iron (Fe) were studied. Results: this review presents an analysis of the chemical effects of resveratrol on oxidative stress associated with the exposure of metal compounds. The interaction of resveratrol with the production of reactive oxygen species (ERO's), the endogenous antioxidant system and its effects on DNA damage is discussed. From these studies, a diagram that shows the proposed interactions for resveratrol; heavy metals As, Cd, Cu, Cr and Fe; and oxidative stress is generated. Conclusions: the studies analyzed show that resveratrol is able to modulate the oxidative stress generated by different heavy metal compounds such as As, Cd, Cu, Cr and Fe.

Key Findings

this review presents an analysis of the chemical effects of resveratrol on oxidative stress associated with the exposure of metal compounds. The interaction of resveratrol with the production of reactive oxygen species (ERO's), the endogenous antioxidant system and its effects on DNA damage is discussed. From these studies, a diagram that shows the proposed interactions for resveratrol; heavy metals As, Cd, Cu, Cr and Fe; and oxidative stress is generated. Conclusions: the studies analyzed show

Outcomes Measured

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Population

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MeSH Terms

  • Antioxidants
  • Cadmium
  • Copper
  • Heavy Metal Poisoning
  • Humans
  • Metals, Heavy
  • Oxidative Stress
  • Resveratrol

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: resveratrol

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09