Melatonin in the treatment of fibromyalgia symptoms: A systematic review
Melatonin in the treatment of fibromyalgia symptoms: A systematic review
Hemati et al., 2020 | Complement Ther Clin Pract | Systematic Review
Citation
Hemati Karim, Amini Kadijani Azade, ... Mirzaei Alireza. Melatonin in the treatment of fibromyalgia symptoms: A systematic review. Complement Ther Clin Pract. 2020-Feb;38:101072. doi:10.1016/j.ctcp.2019.101072
Abstract
The available pharmacological modalities for the treatment of fibromyalgia (FM) are associated with a variety of adverse effects and limited benefits. In this study, we systematically reviewed the impact of melatonin in the treatment of FM. Interventional studies, either controlled or uncontrolled and randomized or non-randomized, were included. PubMed, EMBASE, Scopus, Web of Science, and the Cochrane Library were searched without time limitation. Primary outcome measures were the effect of melatonin on the disease impact, pain, sleep quality, tender point count, fatigue, anxiety, stiffness, and depression in FM patients. Four studies, reporting the effect of melatonin on 98 patients, were eligible to include. All the studies reported the positive effect of melatonin on the FM symptoms. No major adverse event was reported. A significant level of heterogeneity was observed between the studies. Therefore, further high-quality controlled clinical trials are needed to understand the role of melatonin in FM treatment fully.
Key Findings
Therefore, further high-quality controlled clinical trials are needed to understand the role of melatonin in FM treatment fully.
Outcomes Measured
- sleep quality
- anxiety
- depression
Population
| Field | Value |
|---|---|
| Population | See abstract |
| Sample Size | 98 |
| Age Range | See abstract |
| Condition | sleep |
MeSH Terms
- Fatigue
- Fibromyalgia
- Humans
- Melatonin
- Pain
- Randomized Controlled Trials as Topic
Evidence Classification
- Level: Systematic Review
- Publication Types: Journal Article, Systematic Review
- Vertical: melatonin
Provenance
- PMID: 31783341
- DOI: 10.1016/j.ctcp.2019.101072
- PMCID: Not in PMC
- Verified: 2026-04-09 via PubMed E-utilities API
Source extracted via PubMed E-utilities API on 2026-04-09