Effects of Passiflora incarnata Linnaeus on polysomnographic sleep parameters in subjects with insomnia disorder: a double-blind randomized placebo-controlled study

source extracted confidence: high 2026-04-09
#adolescent #adult #double-blind-method #female #humans

Effects of Passiflora incarnata Linnaeus on polysomnographic sleep parameters in subjects with insomnia disorder: a double-blind randomized placebo-controlled study

Lee et al., 2020 | Int Clin Psychopharmacol | Rct

Citation

Lee Jeewon, Jung Han-Young, ... Kim Shin-Gyeom. Effects of Passiflora incarnata Linnaeus on polysomnographic sleep parameters in subjects with insomnia disorder: a double-blind randomized placebo-controlled study. Int Clin Psychopharmacol. 2020-Jan;35(1):29-35. doi:10.1097/YIC.0000000000000291

Abstract

The purpose of the present double-blind randomized placebo-controlled clinical study was to investigate the effects of Passionflower on polysomnographic sleep parameters in subjects with insomnia disorder. A total number 110 adult participants (mean age = 40.47 ± 11.68, Female = 53.6%) met the inclusion criteria of insomnia disorder according to the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders). After randomization, patients received either the Passionflower extract or the placebo for 2 weeks. Patients underwent an overnight polysomnography and completed sleep diaries, Insomnia Severity Index, and Pittsburgh Sleep Quality Index. Within group comparisons were analyzed with paired t-tests or Wilcoxon's signed rank tests, and between-group comparisons were analyzed with independent t-tests or Mann-Whitney U Tests, as appropriate. Total sleep time (TST) was significantly increased in the Passionflower group compared with placebo (Passionflower vs placebo, 23.05 ± 54.26 vs -0.16 ± 53.12; P = 0.049). Sleep efficiency and wake after sleep onset (WASO) significantly improved after 2 weeks in the Passionflower group but there was no difference compared with the placebo group. The current study demonstrated the positive effects of Passionflower on objective sleep parameters including TST on polysomnography in adults with insomnia disorder. Further study is needed to investigate the clinical efficacy of Passionflower on insomnia.

Key Findings

Further study is needed to investigate the clinical efficacy of Passionflower on insomnia.

Outcomes Measured

  • sleep quality
  • sleep efficiency
  • PSQI (Pittsburgh Sleep Quality Index)
  • insomnia severity

Population

Field Value
Population insomnia disorder
Sample Size See abstract
Age Range See abstract
Condition insomnia

MeSH Terms

  • Adolescent
  • Adult
  • Double-Blind Method
  • Female
  • Humans
  • Hypnotics and Sedatives
  • Male
  • Middle Aged
  • Passiflora
  • Plant Extracts
  • Polysomnography
  • Severity of Illness Index
  • Sleep
  • Sleep Initiation and Maintenance Disorders
  • Young Adult

Evidence Classification

  • Level: Rct
  • Publication Types: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
  • Vertical: passionflower

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09