Predictive value of coronary artery calcium score in cardiovascular disease

source extracted confidence: high 2026-04-09
#coronary-artery-disease #humans #predictive-value-of-tests #severity-of-illness-index #vascular-calcification

Predictive value of coronary artery calcium score in cardiovascular disease

Liu et al., 2020 | Front Biosci (Elite Ed) | Meta Analysis

Citation

Liu Shurong, Zheng Xue, ... Sun Kai. Predictive value of coronary artery calcium score in cardiovascular disease. Front Biosci (Elite Ed). 2020-Jan-01;12(1):113-125

Abstract

We investigated coronary heart disease (CHD) and cardiovascular disease (CVD) event rates in a diverse population with a coronary artery calcium score (CACS) of 0 and the role of CACS in the detection of subclinical noncalcified atherosclerotic plaque. A total of 15,884 participants in five studies were included in this meta-analysis. Hazard ratios (HRs) with 95% confidence intervals (95% CIs) were calculated. The results showed that CHD incidence significantly increased with increased CACS (HR=0.05, 95% CI 0.03-0.06, Z=5.82, P=0.002). The CHD rate was low and further increased with CACS of 101-300. With CACS >300, the CHD rate was highest. Similarly, CVD rate was low with CACS of 0, increased with CACS of 1-100 (HR=0.03, 95% CI 0.01-0.06, Z=1.66, P=0.096), and further increased with CACS of 101-300. With CACS >300, the CVD rate was highest. Clinical evidence indicated that the higher the CACS, the higher the CHD and CVD rates, while the CVD rate does not always decreased compared with CHD rate with the same CACS, especially with CACS of 0.

Key Findings

Clinical evidence indicated that the higher the CACS, the higher the CHD and CVD rates, while the CVD rate does not always decreased compared with CHD rate with the same CACS, especially with CACS of 0.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 15884
Age Range See abstract
Condition See abstract

MeSH Terms

  • Coronary Artery Disease
  • Humans
  • Predictive Value of Tests
  • Severity of Illness Index
  • Vascular Calcification

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Systematic Review
  • Vertical: calcium

Provenance

  • PMID: 31585873
  • DOI: (not available)
  • PMCID: Not in PMC
  • Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09