Effect of Berberine on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials
Effect of Berberine on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials
Beba et al., 2019 | Complement Ther Med | Meta Analysis
Citation
Beba Mohammad, Djafarian Kurosh, Shab-Bidar Sakineh. Effect of Berberine on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med. 2019-Oct;46:81-86. doi:10.1016/j.ctim.2019.08.002
Abstract
OBJECTIVES: Clinical evidence suggests the beneficial effects of Berberine (BER) on inflammatory markers. However, these results are controversial. The aim of this systematic review was to assess the effects of BER on C-reactive protein (CRP) using clinical trials in adults. DESIGN: Systematic review and meta-analysis. MAIN OUTCOME MEASURES: We searched randomized controlled trials in PubMed and Scopus up to November 2018. The mean differences (MD) and confidence interval (CI) of CRP (mg/L) concentrations were pooled with a random- or a fixed-effects model depending on the results of heterogeneity tests. RESULTS: Of 1242 studies identified, 5 were included in the meta-analysis. Pooled analysis showed that serum levels of CRP were decreased after BER supplementation (MD:-0.64 mg/L, 95% CI(-0.67 to -0.61) P < 0.001)) without any significant heterogeneity (I2 = 0.0% and P = 0.984). CONCLUSION: This meta-analysis showed BER supplementation may ameliorate the state of chronic inflammation. Patients with cardiovascular disease and diabetes are two important groups which may benefit from BER supplementation. Further well-designed investigations with larger samples are needed to ascertain the long-term effects of BER on chronic inflammation.
Key Findings
Of 1242 studies identified, 5 were included in the meta-analysis. Pooled analysis showed that serum levels of CRP were decreased after BER supplementation (MD:-0.64 mg/L, 95% CI(-0.67 to -0.61) P < 0.001)) without any significant heterogeneity (I2 = 0.0% and P = 0.984).
Outcomes Measured
- C-reactive protein
- inflammatory markers
Population
| Field | Value |
|---|---|
| Population | cardiovascular disease and diabetes |
| Sample Size | 1242 |
| Age Range | See abstract |
| Condition | diabetes |
MeSH Terms
- Berberine
- Biomarkers
- C-Reactive Protein
- Dietary Supplements
- Humans
- Inflammation
- Randomized Controlled Trials as Topic
Evidence Classification
- Level: Meta Analysis
- Publication Types: Journal Article, Meta-Analysis, Systematic Review
- Vertical: berberine
Provenance
- PMID: 31519292
- DOI: 10.1016/j.ctim.2019.08.002
- PMCID: Not in PMC
- Verified: 2026-04-09 via PubMed E-utilities API
Source extracted via PubMed E-utilities API on 2026-04-09