Effect of vitamin D on Helicobacter pylori infection and eradication: A meta-analysis

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#drug-therapy-combination #helicobacter-infections #humans #sensitivity-and-specificity #treatment-outcome

Effect of vitamin D on Helicobacter pylori infection and eradication: A meta-analysis

Yang et al., 2019 | Helicobacter | Meta Analysis

Citation

Yang Liping, He Xinjue, ... Lu Chao. Effect of vitamin D on Helicobacter pylori infection and eradication: A meta-analysis. Helicobacter. 2019-Oct;24(5):e12655. doi:10.1111/hel.12655

Abstract

BACKGROUND: Various studies reported the relationship between Helicobacter pylori (H pylori) and vitamin D, but there is some controversy around that. This study aimed to conduct a meta-analysis to clarify the relationship between vitamin D and H pylori infection, and vitamin D and H pylori eradication. METHODS: Articles published until June 1, 2019, in the PubMed, MEDLINE, and EMBASE databases with English-language medical studies were searched. According to the inclusion criteria, relevant statistical data were extracted to Microsoft Excel and analyzed by STATA15.1. RESULTS: Ten articles were finally included. It was demonstrated that average 25(OH)D level in H pylori-positive patients was lower than H pylori-negative (SMD = -0.53 ng/mL, 95% CI = (-0.91, -0.16 ng/mL)). For H pylori eradication individuals, the result showed that average 25(OH)D level in H pylori successful eradication individuals was higher than unsuccessful (SMD = 1.31 ng/mL, 95% CI = [0.60, 2.02 ng/mL]). In addition, individuals with vitamin D deficiency had lower H pylori eradicate rate (OR = 0.09, 95% CI = [0.02, 0.41]). Sensitivity analysis showed that the meta-analysis results were stable and reliable. CONCLUSIONS: Vitamin D was a protective factor to H pylori infection. Moreover, vitamin D can improve the success rate of H pylori eradication.

Key Findings

Ten articles were finally included. It was demonstrated that average 25(OH)D level in H pylori-positive patients was lower than H pylori-negative (SMD = -0.53 ng/mL, 95% CI = (-0.91, -0.16 ng/mL)). For H pylori eradication individuals, the result showed that average 25(OH)D level in H pylori successful eradication individuals was higher than unsuccessful (SMD = 1.31 ng/mL, 95% CI = [0.60, 2.02 ng/mL]). In addition, individuals with vitamin D deficiency had lower H pylori eradicate rate (OR = 0.0

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population vitamin d deficiency had
Sample Size See abstract
Age Range See abstract
Condition deficiency

MeSH Terms

  • Drug Therapy, Combination
  • Helicobacter Infections
  • Humans
  • Sensitivity and Specificity
  • Treatment Outcome
  • Vitamin D
  • Vitamin D Deficiency

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: vitamin-d-immune

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09