Circulating Selenium and Cardiovascular or All-Cause Mortality in the General Population: a Meta-Analysis

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#cardiovascular-diseases #humans #risk-factors #selenium

Circulating Selenium and Cardiovascular or All-Cause Mortality in the General Population: a Meta-Analysis

Xiang et al., 2020 | Biol Trace Elem Res | Meta Analysis

Citation

Xiang Shouyan, Dai Zhe, ... Fan Yu. Circulating Selenium and Cardiovascular or All-Cause Mortality in the General Population: a Meta-Analysis. Biol Trace Elem Res. 2020-May;195(1):55-62. doi:10.1007/s12011-019-01847-8

Abstract

The association of circulating selenium level with mortality remains controversial. This meta-analysis investigated the association between elevated circulating selenium level and cardiovascular or all-cause mortality in the general population. PubMed and Embase databases (up to January 20, 2019) were searched for observational studies or post hoc analyses of randomized controlled trials that evaluated the association between elevated circulating selenium level and cardiovascular or all-cause mortality in the general population. Twelve observational studies (ten cohort and two case-control studies) with a total of 25,667 individuals were included. Comparison with the lowest and the highest circulating selenium level showed that the pooled risk ratio (RR) values of all-cause mortality and cardiovascular mortality were 1.36 (95% confidence intervals [CI] 1.18-1.58) and 1.35 (95% CI 1.13-1.62), respectively. When analyzed selenium level as a continuous variable, each standard deviation selenium increase significantly reduced 20% all-cause mortality risk. However, the lowest circulating selenium level was not associated with a high risk of coronary mortality (RR 1.43; 95% CI 0.93-2.19). This meta-analysis indicated that low circulating selenium level was associated with higher risk of cardiovascular or all-cause mortality in the general population. Low circulating selenium level did not confer significant effect on coronary death.

Key Findings

Low circulating selenium level did not confer significant effect on coronary death.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 25667
Age Range See abstract
Condition See abstract

MeSH Terms

  • Cardiovascular Diseases
  • Humans
  • Risk Factors
  • Selenium

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Review
  • Vertical: selenium

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09