Effect of omega-3 fatty acid plus vitamin E Co-Supplementation on lipid profile: A systematic review and meta-analysis

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#dietary-supplements #dyslipidemias #fatty-acids-omega-3 #humans #inflammation

Effect of omega-3 fatty acid plus vitamin E Co-Supplementation on lipid profile: A systematic review and meta-analysis

Sepidarkish et al., 2019 | Diabetes Metab Syndr | Meta Analysis

Citation

Sepidarkish Mahdi, Morvaridzadeh Mojgan, ... Heshmati Javad. Effect of omega-3 fatty acid plus vitamin E Co-Supplementation on lipid profile: A systematic review and meta-analysis. Diabetes Metab Syndr. 2019;13(2):1649-1656. doi:10.1016/j.dsx.2019.03.018

Abstract

BACKGROUND: Dyslipidemia is linked to chronic inflammation, which in return leads to a set of chronic disorders. Omega-3 fatty acids have been reported to reduce inflammation. Furthermore, Vitamin E is a fat-soluble vitamin which has antioxidant and anti-inflammatory effects. Vitamin E and omega-3 fatty acids co-supplementations may be more effective than the single supplementation in control dyslipidemia. Therefore, we designed and conducted the current systematic review and meta-analysis to investigate the effect of co-supplementation of vitamin E and omega-3 fatty acids on the lipid profile. METHODS: A comprehensive search for studies published between January 1990 and July 2018 was performed. The initial search extracted 3015 potentially relevant articles. After studying these publications, 9 RCTs were potentially eligible and retrieved in full text. RESULTS: The meta-analysis indicate that on total cholesterol, HDL, LDL and triglyceride individually did not show any significant difference between intervention and control groups, but vitamin E an omega-3 fatty acids co-supplementations significantly reduce VLDL levels. CONCLUSIONS: Based on the available evidence, omega-3 fatty acid and vitamin E co-supplementation can reduce VLDL, although its effect on other lipid profile parameters requires more well-designed studies.

Key Findings

The meta-analysis indicate that on total cholesterol, HDL, LDL and triglyceride individually did not show any significant difference between intervention and control groups, but vitamin E an omega-3 fatty acids co-supplementations significantly reduce VLDL levels.

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population See abstract
Sample Size 9
Age Range See abstract
Condition inflammation

MeSH Terms

  • Dietary Supplements
  • Dyslipidemias
  • Fatty Acids, Omega-3
  • Humans
  • Inflammation
  • Lipids
  • Prognosis
  • Vitamin E

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: vitamin-e

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09