Magnesium intake and lung cancer risk: A systematic review and meta-analysis

source extracted confidence: high 2026-04-09
#humans #lung #lung-neoplasms #magnesium #nutritional-status

Magnesium intake and lung cancer risk: A systematic review and meta-analysis

Dana et al., 2021 | Int J Vitam Nutr Res | Meta Analysis

Citation

Dana Nasim, Karimi Raheleh, ... Vaseghi Golnaz. Magnesium intake and lung cancer risk: A systematic review and meta-analysis. Int J Vitam Nutr Res. 2021-Sep;91(5-6):539-546. doi:10.1024/0300-9831/a000598

Abstract

Magnesium may reduce the risk of lung cancer by affecting cell proliferation, inflammation and by preserving lung function; however, the results of epidemiological studies on the potential benefits of magnesium in lung pathology are inconclusive. We conducted this meta-analysis to investigate the association between magnesium intake and the risk of lung cancer. A total of 5 studies were extracted from PubMed, SCOPUS, and the Cochrane Review (to May 2018). These studies involved 58,5821 participants with 8,977 lung cancer cases. The pooled relative risk (RR) indicated a significant association between lung cancer incidence and magnesium intake (RR = 0.88, 95% CI = 0.79 to 0.98; p = 0.018). To investigate the cause of heterogeneity of these studies (I2 = 75.8%, p < 0.001), we performed a subgroup analysis which was affected by the mean dose of magnesium intake, where doses of magnesium intake lower than 300 mg/d significantly decreased lung cancer risk (RR = 0.83, 95% CI = 0.70 to 0.99; p = 0.034). Increasing magnesium intake doses to over 300 mg/d did not reduce the incidence of lung cancer (RR = 0.89, 95% CI = 0.78 to 1.01; p = 0.076). Our meta-analysis suggests that magnesium intake of less than 300 mg/d may have protective effects in lung cancer.

Key Findings

Our meta-analysis suggests that magnesium intake of less than 300 mg/d may have protective effects in lung cancer.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 585821
Age Range See abstract
Condition inflammation

MeSH Terms

  • Humans
  • Lung
  • Lung Neoplasms
  • Magnesium
  • Nutritional Status
  • Risk
  • Risk Factors

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: magnesium

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09