Omega 3 fatty acid supplementation after myocardial infarction: a systematic review and meta-analysis

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#cause-of-death #dietary-supplements #fatty-acids-omega-3 #humans #myocardial-infarction

Omega 3 fatty acid supplementation after myocardial infarction: a systematic review and meta-analysis

Popoff et al., 2019 | BMC Cardiovasc Disord | Meta Analysis

Citation

Popoff Federico, Balaciano Giselle, ... Izcovich Ariel. Omega 3 fatty acid supplementation after myocardial infarction: a systematic review and meta-analysis. BMC Cardiovasc Disord. 2019-Jun-04;19(1):136. doi:10.1186/s12872-019-1086-3

Abstract

BACKGROUND: The purpose of this review is to examine the effect of Omega-3 Fatty acids on mortality, morbidity, and adverse events in patients with acute myocardial infarction (AMI). METHODS: Data Sources: MEDLINE, EMBASE, and the Cochrane Library through May 2018. STUDY SELECTION: Randomized Controlled trials (RCT). Certainty of evidence was assessed with the GRADE system. INTERVENTIONS: omega 3 fatty acids against placebo or no treatment. Primary and secondary outcomes: All-cause death, cardiovascular death, new AMI, stroke, need for therapeutic angioplasty or By-pass, new diagnosis of cancer and incidence of adverse events. RESULTS: For the efficacy endpoints we included 10 RCT (24,414 patients). Omega 3 fatty acids probably make little or no difference to all-cause mortality (4 studies 9141 patients RR 1.06 - CI95% 0.90 to 1.27, moderate certainty), cardiovascular mortality (3 studies 4304 patients RR 0.93 - CI95% 0.63 to 1.37, moderate certainty), new AMI (RR 1.24 CI95% 0.71 to 2.14 - moderate certainty), any cardiovascular event (RR 0.95 95%CI 0.86 to 1.05; low certainty due to risk of bias and imprecision), and stroke (RR 1.2 95%CCI 0,66-2,19 - moderate certainty). Regarding adverse events, we are uncertain if Omega 3 fatty acids improve/reduce non severe adverse events (RR 1.39 95% CI 0.36 to 5.34; very low certainty). There is probably little or no difference in the outcome suspension due to adverse events (RR 1.19 CI 95% 0.97 to 1.47; moderate certainty). CONCLUSIONS: For adult patients with AMI, omega 3 fatty-acids probably yield no benefit to patient important outcomes.

Key Findings

For the efficacy endpoints we included 10 RCT (24,414 patients). Omega 3 fatty acids probably make little or no difference to all-cause mortality (4 studies 9141 patients RR 1.06 - CI95% 0.90 to 1.27, moderate certainty), cardiovascular mortality (3 studies 4304 patients RR 0.93 - CI95% 0.63 to 1.37, moderate certainty), new AMI (RR 1.24 CI95% 0.71 to 2.14 - moderate certainty), any cardiovascular event (RR 0.95 95%CI 0.86 to 1.05; low certainty due to risk of bias and imprecision), and stroke (

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population acute myocardial infarction
Sample Size 24414
Age Range See abstract
Condition See abstract

MeSH Terms

  • Cause of Death
  • Dietary Supplements
  • Fatty Acids, Omega-3
  • Humans
  • Myocardial Infarction
  • Recurrence
  • Risk Assessment
  • Risk Factors
  • Secondary Prevention
  • Time Factors
  • Treatment Outcome

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: omega-3

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09