Effects of coenzyme Q10 supplementation on diastolic function in patients with heart failure with preserved ejection fraction

source extracted confidence: high 2026-04-09
#aged #diastole #dietary-supplements #female #follow-up-studies

Effects of coenzyme Q10 supplementation on diastolic function in patients with heart failure with preserved ejection fraction

Sobirin et al., 2019 | Drug Discov Ther | Rct

Citation

Sobirin Mochamad Ali, Herry Yan, ... Tsutsui Hiroyuki. Effects of coenzyme Q10 supplementation on diastolic function in patients with heart failure with preserved ejection fraction. Drug Discov Ther. 2019;13(1):38-46. doi:10.5582/ddt.2019.01004

Abstract

Heart failure with preserved ejection fraction (HFpEF) is a leading cause of morbidity and mortality without an established treatment. Diastolic dysfunction, the hallmark of HFpEF, is associated with altered myocardial bioenergetics. No previous study has examined the effects of coenzyme Q10 (CoQ10) on left ventricle (LV) diastolic function in patients with HFpEF. We investigated whether CoQ10 could improve LV diastolic function in patients with HFpEF. We performed a randomized controlled trial (RCT) using pretest and posttest control groups of 30 patients with HFpEF. The patients received either CoQ10 100 mg three times a day or no CoQ10 in addition to routine treatment for 30 days. Echocardiographic study was performed at baseline and follow-up. LV diastolic function was evaluated by two dimensional and Doppler echocardiography as follows; average E/e׳, septal and lateral e׳velocity, and left atrium volume index (LAVI). A total of 28 patients completed the study. A statistically significant improvement was observed in the CoQ10 treatment group in terms between groups (∆E/e׳ ‒ 3.6 vs. ‒ 2.4; p = 0.28) and (∆LAVI ‒ 5.4 vs. ‒ 4.4; p = 0.83). Short term CoQ10 supplementation provided no additional benefits in improving LV diastolic function in patients with HFpEF.

Key Findings

Short term CoQ10 supplementation provided no additional benefits in improving LV diastolic function in patients with HFpEF.

Outcomes Measured

  • diastolic blood pressure

Population

Field Value
Population hfpef
Sample Size 30
Age Range See abstract
Condition See abstract

MeSH Terms

  • Aged
  • Diastole
  • Dietary Supplements
  • Female
  • Follow-Up Studies
  • Heart Failure
  • Humans
  • Male
  • Middle Aged
  • Stroke Volume
  • Ubiquinone
  • Ventricular Function, Left

Evidence Classification

  • Level: Rct
  • Publication Types: Journal Article, Randomized Controlled Trial
  • Vertical: coq10-heart

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09