The reduction of melatonin levels is associated with the development of preeclampsia: a meta-analysis

source extracted confidence: high 2026-04-09
#female #humans #melatonin #pre-eclampsia #pregnancy

The reduction of melatonin levels is associated with the development of preeclampsia: a meta-analysis

Dou et al., 2019 | Hypertens Pregnancy | Meta Analysis

Citation

Dou Yuanyan, Lin Binbin, ... Wu Jing. The reduction of melatonin levels is associated with the development of preeclampsia: a meta-analysis. Hypertens Pregnancy. 2019-May;38(2):65-72. doi:10.1080/10641955.2019.1581215

Abstract

OBJECTIVE: The aim of this analysis was to demonstrate the association between melatonin levels and the development of preeclampsia. METHODS: Standardized mean difference (SMD) with 95% confidence interval (CI) was calculated using a random effects model. RESULTS: The pooled SMD between case and control was 1.40 (95% CI: 0.26, 2.55; P = 0.02). And the pooled SMD between mild PE and severe PE was 5.25 (95% CI: 1.5, 9.01; P = 0.006). CONCLUSION: The meta-analysis illustrated that melatonin concentration was significantly lower in women with preeclampsia, and correlated with the severity of the disease.

Key Findings

The pooled SMD between case and control was 1.40 (95% CI: 0.26, 2.55; P = 0.02). And the pooled SMD between mild PE and severe PE was 5.25 (95% CI: 1.5, 9.01; P = 0.006).

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Female
  • Humans
  • Melatonin
  • Pre-Eclampsia
  • Pregnancy

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Review
  • Vertical: melatonin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09