A systematic review and meta-analysis of randomized controlled trials to evaluating the trend of cytokines to vitamin A supplementation in autoimmune diseases

source extracted confidence: high 2026-04-09
#anti-inflammatory-agents #autoimmune-diseases #cytokines #dietary-supplements #female

A systematic review and meta-analysis of randomized controlled trials to evaluating the trend of cytokines to vitamin A supplementation in autoimmune diseases

Harirchian et al., 2019 | Clin Nutr | Meta Analysis

Citation

Harirchian Mohammad Hossein, Mohammadpour Zinat, ... Bitarafan Sama. A systematic review and meta-analysis of randomized controlled trials to evaluating the trend of cytokines to vitamin A supplementation in autoimmune diseases. Clin Nutr. 2019-Oct;38(5):2038-2044. doi:10.1016/j.clnu.2018.10.026

Abstract

BACKGROUND & AIMS: Vitamin A is considered as a supplement that effect on autoimmune diseases. We aimed to systematically review the effect of vitamin A on cytokines in patients with autoimmune disease. METHODS: Two researchers searched Scopus and PubMed until May 2018. Researchers extracted data from 6 eligible published papers. Extracted data included the gene expression of the inflammatory and anti-inflammatory cytokines. RESULTS: Fixed effect analysis of the WMD (95% CI) of the changes in gene expression showed that gene expression of the inflammatory (IL-17, IFN-γ and T-bet) and anti-inflammatory (TGF-β and FOXP3) cytokines significantly decreased and increased due to vitamin A supplementation in patients with autoimmune (Multiple sclerosis and atherosclerosis) diseases. CONCLUSIONS: Vitamin A supplementation effects on gene expression and may improve serum level of cytokines and clinical signs of autoimmune disease but there is no adequate evidence.

Key Findings

Fixed effect analysis of the WMD (95% CI) of the changes in gene expression showed that gene expression of the inflammatory (IL-17, IFN-γ and T-bet) and anti-inflammatory (TGF-β and FOXP3) cytokines significantly decreased and increased due to vitamin A supplementation in patients with autoimmune (Multiple sclerosis and atherosclerosis) diseases.

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population autoimmune disease
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Anti-Inflammatory Agents
  • Autoimmune Diseases
  • Cytokines
  • Dietary Supplements
  • Female
  • Gene Expression Regulation
  • Humans
  • Male
  • Randomized Controlled Trials as Topic
  • Vitamin A

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Systematic Review
  • Vertical: vitamin-a

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09