The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials

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#caffeine #central-nervous-system-stimulants #dose-response-relationship-drug #humans #weight-loss

The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials

Tabrizi et al., 2019 | Crit Rev Food Sci Nutr | Meta Analysis

Citation

Tabrizi Reza, Saneei Parvane, ... Asemi Zatollah. The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2019;59(16):2688-2696. doi:10.1080/10408398.2018.1507996

Abstract

This systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to summarize the effect of caffeine intake on weight loss. We searched the following databases until November 2017: MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. The relevant data were extracted and assessed for quality of the studies according to the Cochrane risk of bias tool. We estimated an intake-status regression coefficient (Beta) for each primary study and estimated the overall pooled Beta and SE using random effects meta-analysis on a double-log scale. Heterogeneity between studies was assessed by the Cochran Q statistic and I-squared tests (I2). Thirteen RCTs with 606 participants were included in the meta-analyses. The overall pooled Beta for the effect of caffeine intake was 0.29 (95%CI: 0.19, 0.40; Q  =  124.5, I2 = 91.2%) for weigh, 0.23 (95%CI: 0.09, 0.36; Q  =  71.0, I2 = 93.0%) for BMI, and 0.36 (95% CI: 0.24, 0.48; Q  =  167.36, I2 = 94.0%) for fat mass. For every doubling in caffeine intake, the mean reduction in weight, BMI, and fat mass increased 2 Beta-fold (20.29  =  1.22, 20.23  =  1.17, and 20.36  =  1.28), which corresponding to 22, 17, and 28 percent, respectively. Overall, the current meta-analysis demonstrated that caffeine intake might promote weight, BMI and body fat reduction.

Key Findings

Overall, the current meta-analysis demonstrated that caffeine intake might promote weight, BMI and body fat reduction.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 606
Age Range See abstract
Condition See abstract

MeSH Terms

  • Caffeine
  • Central Nervous System Stimulants
  • Dose-Response Relationship, Drug
  • Humans
  • Weight Loss

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: caffeine

Provenance

Source extracted via PubMed E-utilities API on 2026-04-10