The Association between Vitamin D Deficiency and Sleep Disorders: A Systematic Review and Meta-Analysis

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#adolescent #adult #aged #case-control-studies #child

The Association between Vitamin D Deficiency and Sleep Disorders: A Systematic Review and Meta-Analysis

Gao et al., 2018 | Nutrients | Meta Analysis

Citation

Gao Qi, Kou Tingyan, ... Wang Qiuzhen. The Association between Vitamin D Deficiency and Sleep Disorders: A Systematic Review and Meta-Analysis. Nutrients. 2018-Oct-01;10(10). doi:10.3390/nu10101395

Abstract

Epidemiology studies have investigated the association between vitamin D and the risk of sleep disorders, but the results remain controversial. Therefore, we conducted this meta-analysis with the goal of clarifying the association between vitamin D and sleep disorders risk. All relevant studies were searched using PubMed, EMBASE, and Web of Science from inception to January 2018. Pooled odds ratios (ORs) and 95% confidence interval (CIs) were calculated using a fixed-effect model A total of nine studies (6 cross-sectional, 2 case-control, and 1 cohort studies) involving 9397 participants were included. By comparing the lowest verse highest levels of serum vitamin D, we found that participants with vitamin D deficiency (VDD) had a significantly increased risk of sleep disorders (OR: 1.50, 95% CI: 1.31, 1.72). Subgroup analysis showed that VDD also was associated with poor sleep quality (OR: 1.59, 95% CI: 1.23, 2.05), short sleep duration (OR: 1.74, 95% CI: 1.30, 2.32), and sleepiness (OR: 1.36, 95% CI: 1.12, 1.65). Subgroup analyses further indicated that serum 25(OH)D <20 ng/mL could significantly increase the risk of unhealthy sleep. This meta-analysis suggest that vitamin D deficiency is associated with a higher risk of sleep disorders. More high-quality cohort studies and randomized controlled trials (RCTs) are needed to verify this association.

Key Findings

More high-quality cohort studies and randomized controlled trials (RCTs) are needed to verify this association.

Outcomes Measured

  • sleep quality
  • sleep duration

Population

Field Value
Population See abstract
Sample Size 9397
Age Range See abstract
Condition sleep

MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Cohort Studies
  • Cross-Sectional Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Odds Ratio
  • Risk Factors
  • Sleep
  • Sleep Wake Disorders
  • Vitamin D
  • Vitamin D Deficiency
  • Young Adult

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: vitamin-d-sleep

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09