Coenzyme Q10 in the treatment of heart failure: A systematic review of systematic reviews

source extracted confidence: high 2026-04-09
#cardiovascular-diseases #dietary-supplements #humans #treatment-outcome #ubiquinone

Coenzyme Q10 in the treatment of heart failure: A systematic review of systematic reviews

Jafari et al., 2018 | Indian Heart J | Systematic Review

Citation

Jafari Mehdi, Mousavi Seyed Masood, ... Yazdani Neda. Coenzyme Q10 in the treatment of heart failure: A systematic review of systematic reviews. Indian Heart J. 2018-Jul;70 Suppl 1(Suppl 1):S111-S117. doi:10.1016/j.ihj.2018.01.031

Abstract

INTRODUCTION: This article is an attempt to provide an overview of systematic reviews to determine the efficacy of CQ10 supplementation in the treatment of patients with cardiovascular diseases (CVD). METHOD AND MATERIAL: All reviews were identified through a systematic search of the following databases: Cochrane, DARE, Ovid, EMBASE, ISI Web of Knowledge, and PubMed. Check references studies and the quality of the studies was assessed by means of AMSTTAR. No meta-analyses were performed due to the heterogeneity of studies. RESULT: Extracted data for Seven systematic reviews for primary outcomes, net changes in cardiac output, cardiac index, New York Heart Association functional classification, improved survival, based on existing evidence, there is a case for use of CoQ10 as an adjunctive therapy in congestive heart failure, especially in those patients unable to tolerate mainstream medical therapies. CONCLUSION: Evidence suggests that the CoQ10 supplement may be a useful tool for managing patients with heart failure.

Key Findings

Evidence suggests that the CoQ10 supplement may be a useful tool for managing patients with heart failure.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population cardiovascular diseases
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Cardiovascular Diseases
  • Dietary Supplements
  • Humans
  • Treatment Outcome
  • Ubiquinone
  • Vitamins

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: coq10

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09