The effect of garlic on lipid profile and glucose parameters in diabetic patients: A systematic review and meta-analysis

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#adolescent #adult #aged #biomarkers #blood-glucose

The effect of garlic on lipid profile and glucose parameters in diabetic patients: A systematic review and meta-analysis

Shabani et al., 2019 | Prim Care Diabetes | Meta Analysis

Citation

Shabani Ehsan, Sayemiri Korosh, Mohammadpour Mohammadtaghi. The effect of garlic on lipid profile and glucose parameters in diabetic patients: A systematic review and meta-analysis. Prim Care Diabetes. 2019-Feb;13(1):28-42. doi:10.1016/j.pcd.2018.07.007

Abstract

PURPOSE: Several studies have been published about the effect of garlic on lipid profile and blood glucose in diabetic patients. Which, the results mostly contradict with each other. This study aimed to investigate the effect of garlic on lipid profile and serum glucose levels in diabetic patients using a systematic review and meta-analysis. METHODS: This study was a systematic review and meta-analysis of articles published between 1988 and 2016. For this purpose, two independent researchers searched SID medical information databases including MagIran, Irandoc, Medlib, Iran Medex, Science Direct, Scopus, Google and PubMed using keywords. Data were analyzed using STATA software. RESULTS: After the initial search, 23,000 articles were found, of which 33 had the required criteria for the meta-analysis. In the present study, the total sample under review was 1273 individuals, with a mean of 39 samples per study. Overall, the garlic was more influential than placebo in reducing the levels of lipid parameters including triglycerides (TG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), and fasting blood sugar (FBS) and HbA1C. In the meta-analysis, the concentration of serum TC, LDL, TG, and HDL in the group receiving garlic compared with the placebo showed a significant decreased for 16.87mg/dl (95% CI, -21.01, -12.73) (P=0.001), 9.65mg/dl (95% CI, -15.07, -4.23) (P=0.001), 12.44mg/dl (95% CI, -18.19, -6.69) (P=0.001), and increased for 3.19mg/dl (95% CI, 1.85, 4.53) (P=0.001), respectively. Also, the concentration of serum FBS and HbA1C serum showed a significant decreased for 10.90mg/dl (95% CI, -16.40, -5.40) (P=0.001) and 0.60mg/dl (95% CI, -0.98, -0.22) (P=0.001), respectively. CONCLUSION: Garlic can reduce lipid profile as well as glucose parameters and be therapeutically effective in patients suffering from cardiovascular diseases and diabetes.

Key Findings

After the initial search, 23,000 articles were found, of which 33 had the required criteria for the meta-analysis. In the present study, the total sample under review was 1273 individuals, with a mean of 39 samples per study. Overall, the garlic was more influential than placebo in reducing the levels of lipid parameters including triglycerides (TG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), and fasting blood sugar (FBS) and HbA1C. In the meta-analysi

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 1273
Age Range See abstract
Condition diabetes

MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Biomarkers
  • Blood Glucose
  • Child
  • Diabetes Mellitus
  • Female
  • Garlic
  • Glycated Hemoglobin
  • Humans
  • Hypoglycemic Agents
  • Hypolipidemic Agents
  • Lipids
  • Male
  • Middle Aged
  • Plant Extracts
  • Plant Roots
  • Treatment Outcome
  • Young Adult

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: garlic

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09