Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study

source extracted confidence: high 2026-04-09
#administration-oral #adult #collagen-type-i #dietary-supplements #double-blind-method

Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study

Kim et al., 2018 | Nutrients | Rct

Citation

Kim Do-Un, Chung Hee-Chul, ... Lee Boo-Yong. Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients. 2018-Jun-26;10(7). doi:10.3390/nu10070826

Abstract

Collagen-peptide supplementation could be an effective remedy to improve hydration, elasticity, and wrinkling in human skin. The aim of this study was to conduct a double-blind, randomized, placebo-controlled trial to clinically evaluate the effect on human skin hydration, wrinkling, and elasticity of Low-molecular-weight Collagen peptide (LMWCP) with a tripetide (Gly-X-Y) content >15% including 3% Gly-Pro-Hyp. Individuals (n = 64) were randomly assigned to receive either placebo or 1000 mg of LMWCP once daily for 12 weeks. Parameters of skin hydration, wrinkling, and elasticity were assessed at baseline and after 6 weeks and 12 weeks. Compared with the placebo group, skin-hydration values were significantly higher in the LMWCP group after 6 weeks and 12 weeks. After 12 weeks in the LMWCP group, visual assessment score and three parameters of skin wrinkling were significantly improved compared with the placebo group. In case of skin elasticity, one parameter out of three was significantly improved in the LMWCP group from the baseline after 12 weeks, while, compared with the placebo group, two parameters out of three in the LMWCP group were higher with significance after 12 weeks. In terms of the safety of LMWCP, none of the subjects presented adverse symptoms related to the test material during the study period. These results suggest that LMWCP can be used as a health functional food ingredient to improve human skin hydration, elasticity, and wrinkling.

Key Findings

These results suggest that LMWCP can be used as a health functional food ingredient to improve human skin hydration, elasticity, and wrinkling.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 64
Age Range See abstract
Condition See abstract

MeSH Terms

  • Administration, Oral
  • Adult
  • Collagen Type I
  • Dietary Supplements
  • Double-Blind Method
  • Elasticity
  • Female
  • Humans
  • Middle Aged
  • Molecular Weight
  • Oligopeptides
  • Peptide Fragments
  • Protein Hydrolysates
  • Skin
  • Skin Aging
  • Time Factors
  • Treatment Outcome
  • Water

Evidence Classification

  • Level: Rct
  • Publication Types: Journal Article, Randomized Controlled Trial
  • Vertical: collagen-skin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09