Recent Developments in the Role of Coenzyme Q10 for Coronary Heart Disease: a Systematic Review

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#antioxidants #blood-glucose #cardiovascular-diseases #chronic-disease #coronary-disease

Recent Developments in the Role of Coenzyme Q10 for Coronary Heart Disease: a Systematic Review

Ayers et al., 2018 | Curr Atheroscler Rep | Systematic Review

Citation

Ayers Jessica, Cook Jamie, ... Dixon Dave L. Recent Developments in the Role of Coenzyme Q10 for Coronary Heart Disease: a Systematic Review. Curr Atheroscler Rep. 2018-May-16;20(6):29. doi:10.1007/s11883-018-0730-1

Abstract

PURPOSE OF REVIEW: This review examines recent randomized clinical trials evaluating the role of coenzyme Q10 (CoQ10) in the management of coronary heart disease. RECENT FINDINGS: CoQ10 is one of the most commonly used dietary supplements in the USA. Due to its antioxidant and anti-inflammatory effects, CoQ10 has been studied extensively for possible use in managing coronary heart disease. One of the most common applications of CoQ10 is to mitigate statin-associated muscle symptoms (SAMS) based on the theory that SAMS are caused by statin depletion of CoQ10 in the muscle. Although previous studies of CoQ10 for SAMS have produced mixed results, CoQ10 appears to be safe. Because CoQ10 is a cofactor in the generation of adenosine triphosphate, supplementation has also recently been studied in patients with heart failure, which is inherently an energy deprived state. The Q-SYMBIO trial found that CoQ10 supplementation in patients with heart failure not only improved functional capacity, but also significantly reduced cardiovascular events and mortality. Despite these positive findings, a larger prospective trial is warranted to support routine use of CoQ10. Less impressive are the effects of CoQ10 on specific cardiovascular risk factors such as blood pressure, dyslipidemia, and glycemic control. Current evidence does not support routine use of CoQ10 in patients with coronary heart disease. Additional studies are warranted to fully determine the benefit of CoQ10 in patients with heart failure before including it in guideline-directed medical therapy.

Key Findings

CoQ10 is one of the most commonly used dietary supplements in the USA. Due to its antioxidant and anti-inflammatory effects, CoQ10 has been studied extensively for possible use in managing coronary heart disease. One of the most common applications of CoQ10 is to mitigate statin-associated muscle symptoms (SAMS) based on the theory that SAMS are caused by statin depletion of CoQ10 in the muscle. Although previous studies of CoQ10 for SAMS have produced mixed results, CoQ10 appears to be safe. Be

Outcomes Measured

  • blood pressure
  • inflammatory markers

Population

Field Value
Population heart failure
Sample Size See abstract
Age Range See abstract
Condition blood pressure

MeSH Terms

  • Antioxidants
  • Blood Glucose
  • Cardiovascular Diseases
  • Chronic Disease
  • Coronary Disease
  • Diabetes Mellitus
  • Dietary Supplements
  • Dyslipidemias
  • Heart Failure
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Hypertension
  • Muscular Diseases
  • Randomized Controlled Trials as Topic
  • Risk Factors
  • Ubiquinone

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: coq10

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09