Grape Seed Extract Supplementation Attenuates the Blood Pressure Response to Exercise in Prehypertensive Men

source extracted confidence: high 2026-04-09
#adult #blood-pressure #body-mass-index #body-weight #cross-over-studies

Grape Seed Extract Supplementation Attenuates the Blood Pressure Response to Exercise in Prehypertensive Men

Kim et al., 2018 | J Med Food | Rct

Citation

Kim Jong-Kyung, Kim Kyung-Ae, ... Stebbins Charles L. Grape Seed Extract Supplementation Attenuates the Blood Pressure Response to Exercise in Prehypertensive Men. J Med Food. 2018-May;21(5):445-453. doi:10.1089/jmf.2017.0133

Abstract

We tested the hypothesis that exaggerated pressor responses observed in prehypertensive males (N = 9) during dynamic exercise are attenuated following acute dietary supplementation with grape seed extract (GSE) (i.e., a single dose). Effects of placebo and GSE (300 mg) on systolic blood pressure, diastolic blood pressure, mean arterial pressure (MAP), cardiac output (CO), stroke volume (SV), total vascular conductance (TVC), and rate × pressure product (RPP) in response to two submaximal cycling workloads (40% and 60% VO2peak) were compared 2 h after ingestion of GSE or placebo on different days, 1 week apart. Endothelial function was also evaluated using flow-mediated dilation (FMD). Placebo treatment had no effect on any of the variables. GSE supplementation attenuated MAP at both workloads (40% VO2peak: 115 ± 1 vs. 112 ± 2 mmHg; 60% VO2peak: 126 ± 2 vs. 123 ± 2 mmHg) and RPP at the lower workload. Conversely, SV, CO, and TVC were augmented during both workloads. FMD was augmented by GSE (18.9 ± 2.0 vs. 12.4% ± 2.0%). These findings indicate that in exercising prehypertensive males, a single dose of GSE reduces blood pressure, peripheral vasoconstriction, and work of the heart and enhances O2 delivery; effects that may be due, in part, to endothelium-dependent vasodilation. We propose that acute GSE treatment represents an intervention that may minimize potential increases in the risk of cardiovascular events during dynamic exercise in prehypertensives.

Key Findings

We propose that acute GSE treatment represents an intervention that may minimize potential increases in the risk of cardiovascular events during dynamic exercise in prehypertensives.

Outcomes Measured

  • blood pressure
  • systolic blood pressure
  • diastolic blood pressure

Population

Field Value
Population See abstract
Sample Size 9
Age Range See abstract
Condition blood pressure

MeSH Terms

  • Adult
  • Blood Pressure
  • Body Mass Index
  • Body Weight
  • Cross-Over Studies
  • Dietary Supplements
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Endothelium, Vascular
  • Exercise
  • Grape Seed Extract
  • Heart Rate
  • Humans
  • Male
  • Oxygen Consumption
  • Prehypertension
  • Sedentary Behavior
  • Stroke Volume
  • Vasoconstriction
  • Vasodilation
  • Young Adult

Evidence Classification

  • Level: Rct
  • Publication Types: Journal Article, Randomized Controlled Trial
  • Vertical: grape-seed

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09