Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

source extracted confidence: high 2026-04-09
#aged #blood-pressure #caloric-restriction #double-blind-method #female

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

Martens et al., 2018 | Nat Commun | Rct

Citation

Martens Christopher R, Denman Blair A, ... Seals Douglas R. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018-Mar-29;9(1):1286. doi:10.1038/s41467-018-03421-7

Abstract

Nicotinamide adenine dinucleotide (NAD+) has emerged as a critical co-substrate for enzymes involved in the beneficial effects of regular calorie restriction on healthspan. As such, the use of NAD+ precursors to augment NAD+ bioavailability has been proposed as a strategy for improving cardiovascular and other physiological functions with aging in humans. Here we provide the evidence in a 2 × 6-week randomized, double-blind, placebo-controlled, crossover clinical trial that chronic supplementation with the NAD+ precursor vitamin, nicotinamide riboside (NR), is well tolerated and effectively stimulates NAD+ metabolism in healthy middle-aged and older adults. Our results also provide initial insight into the effects of chronic NR supplementation on physiological function in humans, and suggest that, in particular, future clinical trials should further assess the potential benefits of NR for reducing blood pressure and arterial stiffness in this group.

Key Findings

Our results also provide initial insight into the effects of chronic NR supplementation on physiological function in humans, and suggest that, in particular, future clinical trials should further assess the potential benefits of NR for reducing blood pressure and arterial stiffness in this group.

Outcomes Measured

  • blood pressure

Population

Field Value
Population healthy middle
Sample Size See abstract
Age Range See abstract
Condition blood pressure

MeSH Terms

  • Aged
  • Blood Pressure
  • Caloric Restriction
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • NAD
  • Niacinamide
  • Pyridinium Compounds
  • Vascular Stiffness

Evidence Classification

  • Level: Rct
  • Publication Types: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural
  • Vertical: nicotinamide-riboside

Provenance

Source extracted via PubMed E-utilities API on 2026-04-10