Colorectal polyp risk is linked to an elevated level of homocysteine

source extracted confidence: high 2026-04-09
#case-control-studies #colonic-polyps #erythrocytes #folic-acid #homocysteine

Colorectal polyp risk is linked to an elevated level of homocysteine

Sun et al., 2018 | Biosci Rep | Meta Analysis

Citation

Sun Manchun, Sun Manyi, ... Shi Songli. Colorectal polyp risk is linked to an elevated level of homocysteine. Biosci Rep. 2018-Apr-26;38(2). doi:10.1042/BSR20171699

Abstract

Several studies have reported an association between levels of folate, homocysteine, and vitamin B12 and the risk of colorectal polyps. Here, our aim is to examine the possible effect of folate, homocysteine, and vitamin B12 levels on the risk of colorectal polyps by means of meta-analysis based quantitative synthesis. According to our inclusion/exclusion criteria, a total of 13 case-control studies were enrolled. The P-value of the association test, standard mean difference (SMD), and 95% confidence interval (CI) were calculated. Pooled analysis data showed a negative correlation between the risk of colorectal polyps and the levels of serum folate, red blood cell (RBC) folate, or vitamin B12 (all P>0.05). Nevertheless, for homocysteine level, we also observed a statistically significant difference between cases and controls in the overall and subgroup analysis of hospital-based control (HB), population-based control (PB), Chinese, Caucasian, or Asian (all P<0.05, SMD > 0). We found that increased levels of homocysteine may be statistically and significantly related to the risk of colorectal polyps.

Key Findings

We found that increased levels of homocysteine may be statistically and significantly related to the risk of colorectal polyps.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Case-Control Studies
  • Colonic Polyps
  • Erythrocytes
  • Folic Acid
  • Homocysteine
  • Humans
  • Risk Factors
  • Vitamin B 12

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Review
  • Vertical: vitamin-b12

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09