Whether vitamin D was associated with clinical outcome after IVF/ICSI: a systematic review and meta-analysis

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#female #fertilization-in-vitro #humans #pregnancy #pregnancy-outcome

Whether vitamin D was associated with clinical outcome after IVF/ICSI: a systematic review and meta-analysis

Zhao et al., 2018 | Reprod Biol Endocrinol | Meta Analysis

Citation

Zhao Jing, Huang Xi, ... Li Yanping. Whether vitamin D was associated with clinical outcome after IVF/ICSI: a systematic review and meta-analysis. Reprod Biol Endocrinol. 2018-Feb-09;16(1):13. doi:10.1186/s12958-018-0324-3

Abstract

BACKGROUND: There exist contradictive views on whether the vitamin D has association with clinical outcome of in vitro fertilization (IVF) and/or intracytoplasmic sperm injection (ICSI). The present meta-analysis aim to establish whether vitamin D was associated with clinical outcomes of IVF/ICSI. METHODS: MEDLINE, Google Scholar and the Cochrane Library from database inception to March 2017 were searched. Clinical studies, which evaluated the association of vitamin D level and the clinical outcomes after IVF/ICSI, were included. The Main Outcome Measures were clinical pregnancy, ongoing pregnancy, and live birth. RESULTS: In the analysis of clinical pregnancy, 9 cohort studies were included. Of which, 2 studies and 3 studies were identified in analyzing ongoing pregnancy and live birth, respectively. Meta-analysis showed trends toward lower clinical pregnancy [RR 0.91, (95% CI 0.77-1.07)] and higher ongoing pregnancy [RR 1.06, (95% CI 0.95-1.19)] for women with deficient level of vitamin D. The probability of live birth for women with deficient level of vitamin D was significantly lower than cases with sufficient level of vitamin D [RR 0.74, (95% CI 0.58-0.90)]. CONCLUSIONS: Deficient vitamin D was associated with decreased probability of live birth after IVF/ICSI. So vitamin D should be supplied to women with deficient level vitamin D.

Key Findings

In the analysis of clinical pregnancy, 9 cohort studies were included. Of which, 2 studies and 3 studies were identified in analyzing ongoing pregnancy and live birth, respectively. Meta-analysis showed trends toward lower clinical pregnancy [RR 0.91, (95% CI 0.77-1.07)] and higher ongoing pregnancy [RR 1.06, (95% CI 0.95-1.19)] for women with deficient level of vitamin D. The probability of live birth for women with deficient level of vitamin D was significantly lower than cases with sufficient

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 2
Age Range See abstract
Condition See abstract

MeSH Terms

  • Female
  • Fertilization in Vitro
  • Humans
  • Pregnancy
  • Pregnancy Outcome
  • Pregnancy Rate
  • Sperm Injections, Intracytoplasmic
  • Vitamin D

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: vitamin-d-fertility

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09