Ginsenoside Rh1: A Systematic Review of Its Pharmacological Properties

source extracted confidence: high 2026-04-09
#animals #antineoplastic-agents-phytogenic #antioxidants #estrogens #ginsenosides

Ginsenoside Rh1: A Systematic Review of Its Pharmacological Properties

Tam et al., 2018 | Planta Med | Systematic Review

Citation

Tam Dao Ngoc Hien, Truong Duy Hieu, ... Huy Nguyen Tien. Ginsenoside Rh1: A Systematic Review of Its Pharmacological Properties. Planta Med. 2018-Feb;84(3):139-152. doi:10.1055/s-0043-124087

Abstract

Ginsenoside Rh1 is one of major bioactive compounds extracted from red ginseng, which has been increasingly used for enhancing cognition and physical health worldwide. The objective of this study was to review the pharmacological effects of ginsenoside Rh1 in a systematic manner. We performed searches on eight electronic databases including MEDLINE (Pubmed), Scopus, Google Scholar, POPLINE, Global Health Library, Virtual Health Library, the System for Information on Grey Literature in Europe, and the New York Academy of Medicine Grey Literature Report to select the original research publications reporting the biological and pharmacological effects of ginsenoside Rh1 from in vitro and in vivo studies regardless of publication language and study design. Upon applying the inclusion and exclusion criteria, we included a total of 57 studies for our systemic review. Ginsenoside Rh1 exhibited the potent characteristics of anti-inflammatory, antioxidant, immunomodulatory effects, and positive effects on the nervous system. The cytotoxic effects of ginsenoside Rh1 were dependent on different types of cell lines. Other pharmacological effects including estrogenic, enzymatic, anti-microorganism activities, and cardiovascular effects have been mentioned, but the results were considerably diverged. A higher quality of evidence on clinical trial studies is highly recommended to confirm the consistent efficacy of ginsenoside Rh1.

Key Findings

A higher quality of evidence on clinical trial studies is highly recommended to confirm the consistent efficacy of ginsenoside Rh1.

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population See abstract
Sample Size 57
Age Range See abstract
Condition See abstract

MeSH Terms

  • Animals
  • Antineoplastic Agents, Phytogenic
  • Antioxidants
  • Estrogens
  • Ginsenosides
  • Humans
  • Immunologic Factors
  • Nervous System
  • Panax
  • Phytotherapy
  • Plants, Medicinal

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: ginseng

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09