A systematic review of metabolite biomarkers of schizophrenia

source extracted confidence: high 2026-04-09
#biomarkers #databases-bibliographic #fatty-acids-unsaturated #humans #lipid-peroxidation

A systematic review of metabolite biomarkers of schizophrenia

Davison et al., 2018 | Schizophr Res | Systematic Review

Citation

Davison Jennifer, O'Gorman Aoife, ... Cotter David R. A systematic review of metabolite biomarkers of schizophrenia. Schizophr Res. 2018-May;195:32-50. doi:10.1016/j.schres.2017.09.021

Abstract

Current diagnosis of schizophrenia relies exclusively on the potentially subjective interpretation of clinical symptoms and social functioning as more objective biological measurement and medical diagnostic tests are not presently available. The use of metabolomics in the discovery of disease biomarkers has grown in recent years. Metabolomic methods could aid in the discovery of diagnostic biomarkers of schizophrenia. This systematic review focuses on biofluid metabolites associated with schizophrenia. A systematic search of Web of Science and Ovid Medline databases was conducted and 63 studies investigating metabolite biomarkers of schizophrenia were included. A review of these studies revealed several potential metabolite signatures of schizophrenia including reduced levels of essential polyunsaturated fatty acids (EPUFAs), vitamin E and creatinine; and elevated levels of lipid peroxidation metabolites and glutamate. Further research is needed to validate these biomarkers and would benefit from large cohort studies and more homogeneous and well-defined subject groups.

Key Findings

Further research is needed to validate these biomarkers and would benefit from large cohort studies and more homogeneous and well-defined subject groups.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 63
Age Range See abstract
Condition See abstract

MeSH Terms

  • Biomarkers
  • Databases, Bibliographic
  • Fatty Acids, Unsaturated
  • Humans
  • Lipid Peroxidation
  • Metabolomics
  • Schizophrenia
  • Vitamin E

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Research Support, Non-U.S. Gov't, Systematic Review
  • Vertical: vitamin-e

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09