Effect of magnesium supplementation on insulin resistance in humans: A systematic review

source extracted confidence: high 2026-04-09
#blood-glucose #dietary-supplements #humans #hypercalciuria #insulin-resistance

Effect of magnesium supplementation on insulin resistance in humans: A systematic review

Morais et al., 2017 | Nutrition | Systematic Review

Citation

Morais Jennifer Beatriz Silva, Severo Juliana Soares, ... Frota Karoline de Macedo Gonçalves. Effect of magnesium supplementation on insulin resistance in humans: A systematic review. Nutrition. 2017-Jun;38:54-60. doi:10.1016/j.nut.2017.01.009

Abstract

OBJECTIVES: Recent studies have demonstrated that minerals play a role in glucose metabolism disorders in humans. Magnesium, in particular, is an extensively studied mineral that has been shown to function in the management of hyperglycemia, hyperinsulinemia, and insulin resistance (IR) action. The aim of this study was to investigate the effect of magnesium supplementation on IR in humans via systematic review of the available clinical trials. METHODS: This review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. A survey was conducted to select clinical trials related to the effects of this mineral in insulin sensitivity using the following databases: PubMed, SciVerse Scopus, ScienceDirect, and SciVerse Cochrane. RESULTS: After the selection process, 12 articles were identified as eligible, representing different clinical conditions and being free of restriction with regard to sex, age, ethnicity, and differential dosing/shape of magnesium. The results of eight clinical trials showed that supplementation with magnesium influences serum fasting glucose concentrations, and five trials determined an effect on fasting insulin levels. The results of seven studies demonstrated that mineral supplementation reduced homeostasis model assessment for IR values. CONCLUSIONS: The data of this systematic review provide evidence as to the benefits of magnesium supplementation in reducing IR in patients with hypomagnesemia presenting IR. However, new intervention studies are needed to elucidate the role of the nutrient in protection against this metabolic disorder, as well as the standardization of the type, dose, and time of magnesium supplementation.

Key Findings

After the selection process, 12 articles were identified as eligible, representing different clinical conditions and being free of restriction with regard to sex, age, ethnicity, and differential dosing/shape of magnesium. The results of eight clinical trials showed that supplementation with magnesium influences serum fasting glucose concentrations, and five trials determined an effect on fasting insulin levels. The results of seven studies demonstrated that mineral supplementation reduced homeo

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population hypomagnesemia presenting ir
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Blood Glucose
  • Dietary Supplements
  • Humans
  • Hypercalciuria
  • Insulin Resistance
  • Magnesium
  • Nephrocalcinosis
  • Renal Tubular Transport, Inborn Errors

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: magnesium

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09